Human BSE

被引：76

作者：

Almond, J ^{[1
]}

Pattison, J ^{[1
]}

机构：

[1] UNIV LONDON UNIV COLL,SCH MED,LONDON WC1E 6BT,ENGLAND

来源：

NATURE | 1997年 / 389卷 / 6650期

关键词：

D O I：

10.1038/38876

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Two sets of studies, using different approaches, provide convincing evidence that the new variant of Creutzfeldt-Jakob disease (vCJD) is caused by the agent that is responsible for BSE in cattle. Like Creutzfeldt-Jakob disease itself, vCJD is a human neurological disorder that leads to brain damage and death; but it is clinically and pathologically distinct, not least in afflicting younger people. The new studies cannot however tell us anything about a crucial issue — the future number of cases of this variant disease.

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页码：437 / 438

页数：2

相关论文

共 12 条

[1] TRANSMISSION OF BOVINE SPONGIFORM ENCEPHALOPATHY AND SCRAPIE TO MICE - STRAIN VARIATION AND THE SPECIES BARRIER [J].

BRUCE, M ;

CHREE, A ;

MCCONNELL, I ;

FOSTER, J ;

PEARSON, G ;

FRASER, H .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 1994, 343 (1306) :405-411

[2] SCRAPIE STRAIN VARIATION AND MUTATION [J].

BRUCE, ME .

BRITISH MEDICAL BULLETIN, 1993, 49 (04) :822-838

[3] Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent [J].

Bruce, ME ;

Will, RG ;

Ironside, JW ;

McConnell, I ;

Drummond, D ;

Suttie, A ;

McCardle, L ;

Chree, A ;

Hope, J ;

Birkett, C ;

Cousens, S ;

Fraser, H ;

Bostock, CJ .

NATURE, 1997, 389 (6650) :498-501

[4] THE DISEASE CHARACTERISTICS OF DIFFERENT STRAINS OF SCRAPIE IN SINC CONGENIC MOUSE LINES - IMPLICATIONS FOR THE NATURE OF THE AGENT AND HOST CONTROL OF PATHOGENESIS [J].

BRUCE, ME ;

MCCONNELL, I ;

FRASER, H ;

DICKINSON, AG .

JOURNAL OF GENERAL VIROLOGY, 1991, 72 :595-603

[5] Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD [J].

Collinge, J ;

Sidle, KCL ;

Meads, J ;

Ironside, J ;

Hill, AF .

NATURE, 1996, 383 (6602) :685-690

[6] Predicting the CJD epidemic in humans [J].

Cousens, SN ;

Vynnycky, E ;

Zeidler, M ;

Will, RG ;

Smith, PG .

NATURE, 1997, 385 (6613) :197-198

[7] Type of prion protein in UK farmers with Creutzfeldt-Jakob disease [J].

Hill, AF ;

Will, RG ;

Ironside, J ;

Collinge, J .

LANCET, 1997, 350 (9072) :188-188

[8] The same prion strain causes vCJD and BSE [J].

Hill, AF ;

Desbruslais, M ;

Joiner, S ;

Sidle, KCL ;

Gowland, I ;

Collinge, J ;

Doey, LJ ;

Lantos, P .

NATURE, 1997, 389 (6650) :448-450

[9] BSE transmission to macaques [J].

Lasmezas, CI ;

Deslys, JP ;

Demaimay, R ;

Adjou, KT ;

Lamoury, F ;

Dormont, D ;

Robain, O ;

Ironside, J ;

Hauw, JJ .

NATURE, 1996, 381 (6585) :743-744

[10] HOMOZYGOUS PRION PROTEIN GENOTYPE PREDISPOSES TO SPORADIC CREUTZFELDT-JAKOB DISEASE [J].

PALMER, MS ;

DRYDEN, AJ ;

HUGHES, JT ;

COLLINGE, J .

NATURE, 1991, 352 (6333) :340-342