A convenient one-pot three component synthesis of 3-aminoalkylated indoles catalyzed by 3-chlorophenylboronic acid

被引：15

作者：

Goswami, Santosh V. ^{[1
]}

Thorat, Prashant. B. ^{[1
]}

Kadam, Vijay N. ^{[1
]}

Khiste, Sachin A. ^{[1
]}

Bhusare, Sudhakar R. ^{[1
]}

机构：

[1] Dnyanopasak Coll, Dept Chem, Parbhani 431401, Maharashtra, India

来源：

CHINESE CHEMICAL LETTERS | 2013年 / 24卷 / 05期

关键词：

3-Aminoalkylaed indoles; 3-Chlorophenylboronic acid; Aromatic aldehyde; N-Methylaniline; Indoles; NONREARRANGED MONOTERPENOID UNIT; SOLVENT-FREE CONDITIONS; PHENYLBORONIC ACID; EFFICIENT; ALKALOIDS; MILD;

D O I：

10.1016/j.cclet.2013.03.024

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient protocol was developed for the synthesis of 3-aminoalkylated indoles using 3-chlorophenylboronic acid as a catalyst under ambient temperature conditions. The three-component reaction of indoles, aromatic aldehydes and N-methyl aniline offered corresponding 3-aminoalkylated indoles in excellent yields. This protocol presents some remarkable features such as mild reaction conditions, simple workup procedure and excellent yields. (C) 2013 Sudhakar R. Bhusare. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：422 / 424

页数：3

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