Invasive fungal infections in paediatric acute myeloid leukaemia

被引：36

作者：

Johnston, D. L. ^{[1
]}

Lewis, V. ^{[2
]}

Yanofsky, R. ^{[3
]}

Gillmeister, B. ^{[4
]}

Ethier, M. C. ^{[4
]}

Mitchell, D. ^{[5
]}

Cellot, S. ^{[6
]}

Dix, D. ^{[7
]}

Portwine, C. ^{[8
]}

Price, V. ^{[9
]}

Silva, M. ^{[10
]}

Zelcer, S. ^{[11
]}

Michon, B. ^{[12
]}

Bowes, L. ^{[13
]}

Stobart, K. ^{[14
]}

Brossard, J. ^{[15
]}

Beyene, J. ^{[4
,16
]}

Sung, L. ^{[4
,17
]}

机构：

[1] Childrens Hosp Eastern Ontario, Ottawa, ON K1H 8L1, Canada

[2] Alberta Childrens Prov Gen Hosp, Hematol Oncol Transplant Program, Calgary, AB T2T 5C7, Canada

[3] CancerCare Manitoba, Hematol Oncol, Winnipeg, MB, Canada

[4] Hosp Sick Children, Toronto, ON M5G 1X8, Canada

[5] Montreal Childrens Hosp, Montreal, PQ H3H 1P3, Canada

[6] Hosp St Justine, Montreal, PQ, Canada

[7] British Columbia Childrens Hosp, Vancouver, BC V6H 3V4, Canada

[8] Hamilton Hlth Sci, McMaster Childrens Hosp, Hematol Oncol, Hamilton, ON, Canada

[9] IWK Hlth Ctr, Halifax, NS, Canada

[10] Canc Ctr Southeastern Ontario Kingston, Kingston, ON, Canada

[11] London Hlth Sci, Hematol Oncol, London, ON, Canada

[12] Hosp Univ Quebec, Pediat Hematol Oncol Ctr, Quebec City, PQ, Canada

[13] Janeway Child Hlth Ctr, St John, NF, Canada

[14] Univ Alberta Hosp, Stollery Childrens Hosp, Edmonton, AB T6G 2B7, Canada

[15] CHU Sherbrooke, Sherbrooke, PQ J1H 5N4, Canada

[16] McMaster Univ, Dept Clin Epidemiol & Biostat, Populat Genom Program, Hamilton, ON, Canada

[17] Hosp Sick Children, Div Haematol Oncol, Toronto, ON M5G 1X8, Canada

来源：

MYCOSES | 2013年 / 56卷 / 04期

基金：

加拿大健康研究院;

关键词：

Fungal infection; paediatric acute myeloid leukaemia; risk factors; CHILDREN; ASSOCIATION; MYCOSES;

D O I：

10.1111/myc.12063

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Invasive fungal infections (IFIs) are a major cause of morbidity and mortality in paediatric acute myeloid leukaemia (AML). This study describes risk factors for IFI and IFI-related sepsis in this population. We conducted a population-based, retrospective cohort study of children with AML in Canada. IFIs during chemotherapy and prior to haematopoietic stem cell transplantation, relapse, persistent disease or death were identified. Risk factors for proven or probable IFI were examined. Among courses complicated by IFI, risk factors for sepsis were also evaluated. There were 341 children with AML included of which 41 (12.0%) experienced 46 different episodes of IFI. Candida species accounted for 23 (50.0%) of IFIs and Aspergillus spp. accounted for 14 (30.4%). Days of broad-spectrum antibiotics, days of corticosteroids and neutropenia at start of the course were independently associated with IFI. Only days of fever were independently associated with IFI-related sepsis. Invasive fungal infections occurred in 12.0% of paediatric AML patients. Risk factors for IFI and IFI-related sepsis were identified. This knowledge may help to consider targeted strategies.

引用

页码：482 / 487

页数：6

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