Synthesis of cephalosporin-3′-diazeniumdiolates: biofilm dispersing NO-donor prodrugs activated by β-lactamase

被引：47

作者：

Yepuri, Nageshwar Rao ^{[1
]}

Barraud, Nicolas ^{[2
,3
]}

Mohammadi, Nasim Shah ^{[2
,3
]}

Kardak, Bharat G. ^{[1
]}

Kjelleberg, Staffan ^{[2
,3
,4
]}

Rice, Scott A. ^{[2
,3
,4
]}

Kelso, Michael J. ^{[1
]}

机构：

[1] Univ Wollongong, Sch Chem, Wollongong, NSW 2522, Australia

[2] Univ New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia

[3] Univ New S Wales, Ctr Marine Bioinnovat, Sydney, NSW 2052, Australia

[4] Nanyang Technol Univ, Singapore Ctr Environm Life Sci Engn, Singapore 639798, Singapore

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 42期

基金：

英国医学研究理事会;

关键词：

NITRIC-OXIDE; BACTERIAL BIOFILMS; DIAZENIUMDIOLATE; CEPHALOSPORIN; ESTERS; ISOMERIZATION; CHEMISTRY; AGENTS;

D O I：

10.1039/c3cc40869h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Use of biofilm dispersing NO-donor compounds in combination with antibiotics has emerged as a promising new strategy for treating drug-resistant bacterial biofilm infections. This paper details the synthesis and preliminary evaluation of six cephalosporin-3 '-diazeniumdiolates as biofilm-targeted NO-donor prodrugs. Each of the compounds is shown to selectively release NO following reaction with the bacteria-specific enzyme beta-lactamase and to trigger dispersion of Pseudomonas aeruginosa biofilms in vitro.

引用

页码：4791 / 4793

页数：3

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