Synthesis, Crystal Structure and Biological Properties of One Zinc(II) Complex Based on 4-Acyl Pyrazolone Derivative

被引：0

作者：

He Chuan-Chuan ^{[1
]}

Li Yue ^{[1
]}

Zhao Jing ^{[2
]}

Xu Guan-Cheng ^{[1
]}

Sun Su-Rong ^{[2
]}

机构：

[1] Xinjiang Univ, Inst Appl Chem, Key Lab Mat & Technol Clean Energy, Key Lab Adv Funct Mat,Minist Educ, Urumqi 830046, Peoples R China

[2] Xinjiang Univ, Coll Life Sci & Technol, Xinjiang Key Lab Biol Resources & Genet Engn, Urumqi 830046, Peoples R China

来源：

CHINESE JOURNAL OF STRUCTURAL CHEMISTRY | 2015年 / 34卷 / 07期

基金：

美国国家科学基金会;

关键词：

zinc(II) complex; 4-acyl pyrazolone derivative; crystal structure; DNA-binding; antitumor activity; DNA-BINDING PROPERTIES; SCHIFF-BASE; COPPER(II) COMPLEXES; N(4)-SUBSTITUTED THIOSEMICARBAZONES; MOLECULAR-STRUCTURE; CO(III) COMPLEXES; CU(II) COMPLEXES; METAL-COMPLEXES; SEMICARBAZONE; LIGANDS;

D O I：

暂无

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

[Zn(L)(CH3OH)(3)] (H2L = N-(1-phenyl-3-methyl-4-propenylidene-5-pyrazolone)-salicylidene hydrazide) has been synthesized by the reaction of zinc nitrate and ligand H2L. The complex crystallizes in orthorhombic system, space group Pbca with a = 5.888(15), b = 14.564(14), c = 22.20(2) angstrom, V= 5137(8) angstrom(3), Z = 8 and F(000) = 2184. The ligand serves as a negative bivalent tridentate chelating agent to coordinate with the central zinc(II) atom. DNA-binding was studied by UV-Vis spectral analysis and ethidium bromide (EB) displacement experiments. The results showed that the DNA-binding constant of the complex is 5.1 X 10(4) M-1. Antitumor activity of [Zn(L)(CH3OH)(3)] and the ligand have been investigated by MTT assay, which indicated that the complex has better cytotoxicity to Eca-109 and HeLa than free ligand.

引用

页码：1019 / 1027

页数：9

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