Mild and Selective Cobalt-Catalyzed Chemodivergent Transfer Hydrogenation of Nitriles

被引：161

作者：

Shao, Zhihui ^{[1
,2
]}

Fu, Shaomin ^{[1
]}

Wei, Mufeng ^{[1
]}

Zhou, Shaolin ^{[2
]}

Liu, Qiang ^{[1
]}

机构：

[1] Tsinghua Univ, Dept Chem, Ctr Basic Mol Sci, Beijing 100084, Peoples R China

[2] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 47期

关键词：

amines; cobalt; nitriles; reductive amination; transfer hydrogenation; ASYMMETRIC ALKENE HYDROGENATION; PRIMARY AMINES; TERTIARY-AMINES; PINCER COMPLEX; RUTHENIUM COMPLEXES; HYDRIDE COMPLEXES; SECONDARY-AMINES; NITRO-COMPOUNDS; AMMONIA-BORANE; N-ALKYLATION;

D O I：

10.1002/anie.201608345

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we describe a selective cobalt-catalyzed chemodivergent transfer hydrogenation of nitriles to synthesize primary, secondary, and tertiary amines. The solvent effect plays a key role for the selectivity control. The general applicability of this procedure was highlighted by the synthesis of more than 70 amine products bearing various functional groups in high chemoselectivity. Moreover, this mild system achieved >2000 TONs (turnover numbers) for the transfer hydrogenation of nitriles.

引用

页码：14653 / 14657

页数：5

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