High-resolution chromophore concentration recovery using multi-wavelength Photo-Magnetic Imaging

被引:6
作者
Algarawi, Maha [1 ,2 ]
Nouizi, Farouk [1 ,2 ]
Luk, Alex [1 ,2 ]
Mehrabi, Mehrnaz [1 ,2 ]
Erkol, Hakan [4 ]
Ha, Seunghoon [3 ]
Unlu, Mehmet Burcin [4 ]
Gulsen, Gultekin [1 ,2 ]
机构
[1] Univ Calif Irvine, Dept Radiol Sci, Ctr Funct Oncoimaging, Irvine, CA 92717 USA
[2] Univ Calif Irvine, Dept Phys & Astron, Irvine, CA 92697 USA
[3] Philips Healthcare, Pewaukee, WI USA
[4] Bogazici Univ, Dept Phys, Istanbul, Turkey
来源
MULTIMODAL BIOMEDICAL IMAGING XIV | 2019年 / 10871卷
基金
美国国家卫生研究院;
关键词
Photo-Magnetic Imaging; Medical and biological imaging; Image reconstruction techniques; Tissue characterization; OPTICAL TOMOGRAPHY; FLUORESCENCE TOMOGRAPHY; QUANTIFICATION; INFORMATION; ALGORITHM; ACCURACY;
D O I
10.1117/12.2504310
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Although diffuse optical tomography (DOT) is able to obtain valuable functional information, its routine use in clinic is hampered by its poor spatial resolution and quantitative accuracy. Previously, our team introduced Photo-Magnetic Imaging (PMI) to overcome the limitation of DOT. PMI is a hybrid modality that synergistically utilizes optics and Magnetic Resonance Imaging (MRI). While illuminating the imaged medium by near-infrared laser, the induced internal temperature increase is measured using Magnetic Resonance Thermometry (MRT). Using these MRT maps, optical absorption maps at the laser's wavelength can be recovered using the dedicated PMI image reconstruction algorithm. In this paper, we present the result of the first validation simulation study of multi-wavelength PMI that utilizes five different laser wavelengths ranging between 760 and 980 nm. Using the high resolution wavelength specific absorption maps, PMI successfully recovered the concentration of three dyes, used as chromophore in the composition of our phantom, with high spatial resolution and quantitative accuracy. By providing functional information at high resolution, multi-wavelength PMI will be a valuable tool for monitoring tissue physiology, cancer detection and monitoring.
引用
收藏
页数:8
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