A Retrospective Multicentric Study of Ewing Sarcoma Family of Tumors in Patients Older Than 50: Management and Outcome

被引：11

作者：

Rochefort, Pauline ^{[1
]}

Italiano, Antoine ^{[2
]}

Laurence, Valerie ^{[3
]}

Penel, Nicolas ^{[4
]}

Lardy-Cleaud, Audrey

Mir, Olivier ^{[5
]}

Chevreau, Christine ^{[6
]}

Bertucci, Francois ^{[7
]}

Bompas, Emmanuelle ^{[8
]}

Chaigneau, Loic ^{[9
]}

Levy, Dominique ^{[3
]}

Ryckewaert, Thomas ^{[4
]}

Dumont, Sarah ^{[5
]}

Meeus, Pierre ^{[1
]}

Ranchere, Dominique ^{[10
]}

Blay, Jean-Yves ^{[1
,11
]}

Cassier, Philippe Alexandre ^{[1
]}

机构：

[1] Ctr Leon Berard, Dept Med Oncol, Lyon, France

[2] Inst Bergonie, Dept Med Oncol, Bordeaux, France

[3] Inst Curie, Dept Med Oncol, Paris, France

[4] Ctr Oscar Lambret, Dept Med Oncol, Lille, France

[5] Gustave Roussy, Dept Med Oncol, Villejuif, France

[6] Inst Claudius Regaud, Dept Med Oncol, Toulouse, France

[7] Inst Paoli Calmettes, Dept Med Oncol, Marseille, France

[8] Ctr Rene Gauducheau, Dept Med Oncol, St Herblain, France

[9] Hop Jean Minjoz, Dept Med Oncol, Besancon, France

[10] Ctr Leon Berard, Dept Pathol, Lyon, France

[11] Univ Claude Bernard, Lyon, France

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

关键词：

INTERVAL-COMPRESSED CHEMOTHERAPY; PRIMITIVE NEUROECTODERMAL TUMOR; PROGNOSTIC-FACTORS; ADULT PATIENTS; SURVIVAL; IFOSFAMIDE; ONCOLOGY; AGE; CYCLOPHOSPHAMIDE; ETOPOSIDE;

D O I：

10.1038/s41598-017-17733-z

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Ewing's sarcoma family of tumors (EFTs) is a group of rare and aggressive tumors. Data on EFTs in patients (pts) >= 50 years are limited and these pts are often not eligible for clinical trials. Some, but not all, studies have reported inferior outcome for older pts with EFTs. We conducted an IRB-approved retrospective analysis among centers of the French Sarcoma Group on pts diagnosed with EFTs at age >= 50 between 2000 and 2012. Clinical features, treatment modality and outcomes were analyzed. Seventy-seven pts were identified, including 36 females (46.8%) and the median age at diagnosis was 56 years (range: 50-86). The primary tumor was located in soft tissue in 59 pts (76.6%). Fifty-six pts (72.7%) had localized disease, among them 49 (87.5%) received chemotherapy in addition to local therapy. Their estimated 3-yr OS and event-free survival (EFS) rates were respectively 73.3% and 62.2%. Recurrence occurred in 43 pts. The estimated 3-yr OS rate was 37% in pts with metastatic disease at presentation. EFTs in pts >= 50 years are more likely to originate from soft tissue and their outcomes appear to be worse than that of younger pts treated with modern protocols.

引用

页数：7

共 40 条

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