Antitumour polycyclic acridines. : Part 9. : Synthesis of 7H-pyrido[4,3,2-kl]acridines with basic side chains

被引：7

作者：

Ellis, MJ ^{[1
]}

Stevens, MFG ^{[1
]}

机构：

[1] Univ Nottingham, Sch Pharmaceut Sci, Canc Res Labs, Nottingham NG7 2RD, England

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2001年 / Royal Society of Chemistry卷 / 23期

关键词：

D O I：

10.1039/b106324n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[3 + 2] Cycloaddition of 3-(dialkylamino)-1-triphenylphosphoranylidenepropan-2-ones and 9-azidoacridine affords 9-[5-(dialkylaminomethyl)-1H-1,2,3-triazol-1-yl] acridines. Graebe-Ullmann thermolysis of the triazoles has been guided by differential scanning calorimetry to predict the optimum temperature for nitrogen extrusion. Boiling diphenyl ether (bp 259 degreesC) is a suitable solvent to convert the triazolylacridines to 2-(dialkylaminomethyl)-7H-pyrido[4,3,2-kl]acridines.

引用

页码：3174 / 3179

页数：6

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