Cu-Catalyzed [4+1] Annulation toward Indolo[2,1-a]isoquinolines through Oxidative C(sp3)/C(sp2)-H Bond Bifunctionalization

被引：15

作者：

Zhang, Tian-Shu ^{[1
]}

Zhao, Qi ^{[1
]}

Hao, Wen-Juan ^{[1
]}

Tu, Shu-Jiang ^{[1
]}

Jiang, Bo ^{[1
]}

机构：

[1] Jiangsu Normal Univ, Sch Chem & Mat Sci, Xuzhou 221116, Jiangsu, Peoples R China

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2019年 / 14卷 / 07期

关键词：

carbonylation; copper; organic chemistry; oxidation; synthetic methods; RECEPTOR-BINDING AFFINITIES; ALPHA-DIAZO CARBONYLS; H BONDS; C(SP(3))-H BONDS; TANDEM SYNTHESIS; ACTIVATION; CONSTRUCTION; ADJACENT; NITROGEN; FUNCTIONALIZATION;

D O I：

10.1002/asia.201900050

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A Cu-catalyzed [4+1] annulation of N-aryl-1,2,3,4-tetrahydroisoquinolines (N-aryl THIQs) with alpha-diazoketones has been established under oxidative conditions, leading to the construction of a series of indolo[2,1-a]isoquinolines with generally good yields. The reaction enables dediazotized dicarbonylation of alpha-diazoketones, creating direct C(sp(3))/C(sp(2))-H bond bifunctionalization to access tetracyclic aza-heterocyclic skeletons.

引用

页码：1042 / 1049

页数：8

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