Practical Synthesis of Functionalized Chromeno[3,4-c]pyridine Derivatives via a CuCl2-Catalyzed Tandem Reaction of the Blaise Reaction Intermediates and 3-Cyanocoumarins

被引：4
|
作者：
Fan, Yangyang [1 ]
Zheng, Lei [1 ]
Yang, Zhaohai [1 ]
Li, Jian-Jun [1 ,2 ]
Chen, Zhiwei [1 ,2 ]
机构：
[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China
[2] Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Zhejiang, Peoples R China
来源：
SYNLETT | 2018年 / 29卷 / 07期
基金：
中国国家自然科学基金;
关键词：
tandem reaction; CuCl2-catalyzed; Blaise reaction intermediates; 3-cyanocoumarins; chromeno[3,4-c]pyridines; ONE-POT SYNTHESIS; POLYSUBSTITUTED PYRIDINES; MULTICOMPONENT SYNTHESIS; BIOLOGICAL-ACTIVITY; ANTITUMOR AGENTS; COUMARINS; CYCLIZATION;
D O I：
10.1055/s-0036-1591535
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
This work discloses a novel and efficient protocol for the construction of functionalized chromeno[3,4-c]pyridine derivatives from the Blaise reaction intermediates and 3-cyanocoumarins through a CuCl2-catalyzed sequential Michael addition/intramolecular cyclization/oxidative aromatization reaction. This new method shows the advantages of mild reaction conditions, easy workup, nonchromato-graphic purification technique, good functional group tolerance, and moderate to good yields.
引用
收藏
页码：959 / 963
页数：5
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