Practical Synthesis of Functionalized Chromeno[3,4-c]pyridine Derivatives via a CuCl2-Catalyzed Tandem Reaction of the Blaise Reaction Intermediates and 3-Cyanocoumarins

被引：4

作者：

Fan, Yangyang ^{[1
]}

Zheng, Lei ^{[1
]}

Yang, Zhaohai ^{[1
]}

Li, Jian-Jun ^{[1
,2
]}

Chen, Zhiwei ^{[1
,2
]}

机构：

[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China

[2] Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Zhejiang, Peoples R China

来源：

SYNLETT | 2018年 / 29卷 / 07期

基金：

中国国家自然科学基金;

关键词：

tandem reaction; CuCl2-catalyzed; Blaise reaction intermediates; 3-cyanocoumarins; chromeno[3,4-c]pyridines; ONE-POT SYNTHESIS; POLYSUBSTITUTED PYRIDINES; MULTICOMPONENT SYNTHESIS; BIOLOGICAL-ACTIVITY; ANTITUMOR AGENTS; COUMARINS; CYCLIZATION;

D O I：

10.1055/s-0036-1591535

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This work discloses a novel and efficient protocol for the construction of functionalized chromeno[3,4-c]pyridine derivatives from the Blaise reaction intermediates and 3-cyanocoumarins through a CuCl2-catalyzed sequential Michael addition/intramolecular cyclization/oxidative aromatization reaction. This new method shows the advantages of mild reaction conditions, easy workup, nonchromato-graphic purification technique, good functional group tolerance, and moderate to good yields.

引用

页码：959 / 963

页数：5

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