Tissue phantoms in multicenter clinical trials for diffuse optical technologies

被引：59

作者：

Cerussi, Albert E. ^{[1
]}

Warren, Robert ^{[1
]}

Hill, Brian ^{[1
]}

Roblyer, Darren ^{[1
]}

Leproux, Anais ^{[1
]}

Durkin, Amanda F. ^{[1
]}

O'Sullivan, Thomas D. ^{[1
]}

Keene, Sam ^{[1
]}

Haghany, Hosain ^{[1
]}

Quang, Timothy ^{[1
]}

Mantulin, William M. ^{[1
]}

Tromberg, Bruce J. ^{[1
]}

机构：

[1] Univ Calif Irvine, Beckman Laser Inst, Irvine, CA 92617 USA

来源：

BIOMEDICAL OPTICS EXPRESS | 2012年 / 3卷 / 05期

基金：

美国国家卫生研究院;

关键词：

PHOTON MIGRATION; SPECTROSCOPY; WATER;

D O I：

10.1364/BOE.3.000966

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Tissue simulating phantoms are an important part of instrumentation validation, standardization/training and clinical translation. Properly used, phantoms form the backbone of sound quality control procedures. We describe the development and testing of a series of optically turbid phantoms used in a multi-center American College of Radiology Imaging Network (ACRIN) clinical trial of Diffuse Optical Spectroscopic Imaging (DOSI). The ACRIN trial is designed to measure the response of breast tumors to neoadjuvant chemotherapy. Phantom measurements are used to determine absolute instrument response functions during each measurement session and assess both long and short-term operator and instrument reliability. (c) 2012 Optical Society of America

引用

页码：966 / 971

页数：6

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