Human Vδ2 versus non-Vδ2 γδ T cells in antitumor immunity

被引：63

作者：

Kabelitz, Dieter ^{[1
]}

Kalyan, Shirin ^{[1
]}

Oberg, Hans-Heinrich ^{[1
]}

Wesch, Daniela ^{[1
]}

机构：

[1] Univ Kiel, Inst Immunol, Kiel, Germany

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 03期

关键词：

V1 T cells; V2 T cells; cancer immunosurveillance; cytotoxicity; T cells; CYTOMEGALOVIRUS-INFECTED CELLS; CYTOTOXICITY RECEPTOR NKP30; MUTS HOMOLOG 2; TUMOR-CELLS; IN-VIVO; STRESS-SURVEILLANCE; MULTIPLE-MYELOMA; CANCER; IMMUNOTHERAPY; LYMPHOCYTES;

D O I：

10.4161/onci.23304

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The V2 and non-V2 (mainly V1) subsets of human T cells have distinct homing patterns and recognize different types of ligands, yet both exert potent antitumor effects. While the T-cell receptor of V2 T cells primarily recognizes tumor cell-derived pyrophosphates, non-V2 T cells preferentially recognize stress-associated surface antigens. Here, we discuss the pros and cons of V2 versus non-V2 T cells as tools for future immunotherapeutic interventions against cancer.

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页数：6

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