Induction of the Unfolded Protein Response during Bovine Alphaherpesvirus 1 Infection
被引:5
作者:
Wang, Song
论文数: 0引用数: 0
h-index: 0
机构:
Shandong Normal Univ, Coll Life Sci, Ruminant Dis Res Ctr, Jinan 250014, Peoples R China
Shandong Normal Univ, Coll Life Sci, Key Lab Anim Resistant Biol Shandong, Jinan 250014, Peoples R ChinaShandong Normal Univ, Coll Life Sci, Ruminant Dis Res Ctr, Jinan 250014, Peoples R China
Wang, Song
[1
,2
]
Ma, Xiaomei
论文数: 0引用数: 0
h-index: 0
机构:
Shandong Normal Univ, Coll Life Sci, Ruminant Dis Res Ctr, Jinan 250014, Peoples R China
Shandong Normal Univ, Coll Life Sci, Key Lab Anim Resistant Biol Shandong, Jinan 250014, Peoples R ChinaShandong Normal Univ, Coll Life Sci, Ruminant Dis Res Ctr, Jinan 250014, Peoples R China
Ma, Xiaomei
[1
,2
]
Wang, Hongmei
论文数: 0引用数: 0
h-index: 0
机构:
Shandong Normal Univ, Coll Life Sci, Ruminant Dis Res Ctr, Jinan 250014, Peoples R China
Shandong Normal Univ, Coll Life Sci, Key Lab Anim Resistant Biol Shandong, Jinan 250014, Peoples R ChinaShandong Normal Univ, Coll Life Sci, Ruminant Dis Res Ctr, Jinan 250014, Peoples R China
Wang, Hongmei
[1
,2
]
He, Hongbin
论文数: 0引用数: 0
h-index: 0
机构:
Shandong Normal Univ, Coll Life Sci, Ruminant Dis Res Ctr, Jinan 250014, Peoples R China
Shandong Normal Univ, Coll Life Sci, Key Lab Anim Resistant Biol Shandong, Jinan 250014, Peoples R ChinaShandong Normal Univ, Coll Life Sci, Ruminant Dis Res Ctr, Jinan 250014, Peoples R China
He, Hongbin
[1
,2
]
机构:
[1] Shandong Normal Univ, Coll Life Sci, Ruminant Dis Res Ctr, Jinan 250014, Peoples R China
[2] Shandong Normal Univ, Coll Life Sci, Key Lab Anim Resistant Biol Shandong, Jinan 250014, Peoples R China
来源:
VIRUSES-BASEL
|
2020年
/
12卷
/
09期
基金:
中国国家自然科学基金;
关键词:
ER stress;
UPR;
BoHV-1;
viral replication;
ER STRESS;
KINASE;
REPLICATION;
INHIBITION;
CHAPERONE;
PROTEOLYSIS;
EXPRESSION;
GRP78/BIP;
PATHWAY;
DISEASE;
D O I:
10.3390/v12090974
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
Bovine herpesvirus 1 (BoHV-1) is an alphaherpesvirus that causes great economic losses in the cattle industry. Herpesvirus infection generally induces endoplasmic reticulum (ER) stress, and the unfolded protein response (UPR) in infected cells. However, it is not clear whether ER stress and UPR can be induced by BoHV-1 infection. Here, we found that ER stress induced by BoHV-1 infection could activate all three UPR sensors (the activating transcription factor 6 (ATF6), the inositol-requiring enzyme 1 (IRE1), and the protein kinase RNA-like ER kinase (PERK)) in MDBK cells. During BoHV-1 infection, the ATF6 pathway of UPR did not affect viral replication. However, both knockdown and specific chemical inhibition of PERK attenuated the BoHV-1 proliferation, and chemical inhibition of PERK significantly reduced the viral replication at the post-entry step of the BoHV-1 life cycle. Furthermore, knockdown of IRE1 inhibits BoHV-1 replication, indicating that the IRE1 pathway may promote viral replication. Further study revealed that BoHV-1 replication was enhanced by IRE1 RNase activity inhibition at the stage of virus post-entry in MDBK cells. Furthermore, IRE1 kinase activity inhibition and RNase activity enhancement decrease BoHV1 replication via affecting the virus post-entry step. Our study revealed that BoHV-1 infection activated all three UPR signaling pathways in MDBK cells, and BoHV-1-induced PERK and IRE1 pathways may promote viral replication. This study provides a new perspective for the interactions of BoHV-1 and UPR, which is helpful to further elucidate the mechanism of BoHV-1 pathogenesis.
机构:
Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R ChinaChinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R China
Cao, Liyan
Xue, Mei
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R ChinaChinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R China
Xue, Mei
Chen, Jianfei
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R ChinaChinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R China
Chen, Jianfei
Shi, Hongyan
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R ChinaChinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R China
Shi, Hongyan
Zhang, Xin
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R ChinaChinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R China
Zhang, Xin
Shi, Da
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R ChinaChinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R China
Shi, Da
Liu, Jianbo
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h-index: 0
机构:
Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R ChinaChinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R China
Liu, Jianbo
Huang, Liping
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h-index: 0
机构:
Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R ChinaChinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R China
Huang, Liping
Wei, Yanwu
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R ChinaChinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R China
Wei, Yanwu
Liu, Changming
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R ChinaChinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R China
Liu, Changming
Feng, Li
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h-index: 0
机构:
Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R ChinaChinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R China
机构:
Shandong Normal Univ, Coll Life Sci, Ruminant Dis Res Ctr, 88 Wenhua E Rd, Jinan 250014, Peoples R ChinaShandong Normal Univ, Coll Life Sci, Ruminant Dis Res Ctr, 88 Wenhua E Rd, Jinan 250014, Peoples R China
Chen, Lihui
Li, Xingyu
论文数: 0引用数: 0
h-index: 0
机构:
Shandong Normal Univ, Coll Life Sci, Ruminant Dis Res Ctr, 88 Wenhua E Rd, Jinan 250014, Peoples R ChinaShandong Normal Univ, Coll Life Sci, Ruminant Dis Res Ctr, 88 Wenhua E Rd, Jinan 250014, Peoples R China
Li, Xingyu
Wang, Hongmei
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h-index: 0
机构:
Shandong Normal Univ, Coll Life Sci, Ruminant Dis Res Ctr, 88 Wenhua E Rd, Jinan 250014, Peoples R ChinaShandong Normal Univ, Coll Life Sci, Ruminant Dis Res Ctr, 88 Wenhua E Rd, Jinan 250014, Peoples R China
Wang, Hongmei
Hou, Peili
论文数: 0引用数: 0
h-index: 0
机构:
Shandong Normal Univ, Coll Life Sci, Ruminant Dis Res Ctr, 88 Wenhua E Rd, Jinan 250014, Peoples R ChinaShandong Normal Univ, Coll Life Sci, Ruminant Dis Res Ctr, 88 Wenhua E Rd, Jinan 250014, Peoples R China
Hou, Peili
He, Hongbin
论文数: 0引用数: 0
h-index: 0
机构:
Shandong Normal Univ, Coll Life Sci, Ruminant Dis Res Ctr, 88 Wenhua E Rd, Jinan 250014, Peoples R ChinaShandong Normal Univ, Coll Life Sci, Ruminant Dis Res Ctr, 88 Wenhua E Rd, Jinan 250014, Peoples R China
机构:
Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R ChinaChinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R China
Cao, Liyan
Xue, Mei
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R ChinaChinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R China
Xue, Mei
Chen, Jianfei
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R ChinaChinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R China
Chen, Jianfei
Shi, Hongyan
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R ChinaChinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R China
Shi, Hongyan
Zhang, Xin
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h-index: 0
机构:
Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R ChinaChinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R China
Zhang, Xin
Shi, Da
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R ChinaChinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R China
Shi, Da
Liu, Jianbo
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R ChinaChinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R China
Liu, Jianbo
Huang, Liping
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R ChinaChinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R China
Huang, Liping
Wei, Yanwu
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R ChinaChinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R China
Wei, Yanwu
Liu, Changming
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R ChinaChinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R China
Liu, Changming
Feng, Li
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R ChinaChinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, 678 Haping Rd, Harbin 150069, Heilongjiang, Peoples R China
机构:
Shandong Normal Univ, Coll Life Sci, Ruminant Dis Res Ctr, 88 Wenhua E Rd, Jinan 250014, Peoples R ChinaShandong Normal Univ, Coll Life Sci, Ruminant Dis Res Ctr, 88 Wenhua E Rd, Jinan 250014, Peoples R China
Chen, Lihui
Li, Xingyu
论文数: 0引用数: 0
h-index: 0
机构:
Shandong Normal Univ, Coll Life Sci, Ruminant Dis Res Ctr, 88 Wenhua E Rd, Jinan 250014, Peoples R ChinaShandong Normal Univ, Coll Life Sci, Ruminant Dis Res Ctr, 88 Wenhua E Rd, Jinan 250014, Peoples R China
Li, Xingyu
Wang, Hongmei
论文数: 0引用数: 0
h-index: 0
机构:
Shandong Normal Univ, Coll Life Sci, Ruminant Dis Res Ctr, 88 Wenhua E Rd, Jinan 250014, Peoples R ChinaShandong Normal Univ, Coll Life Sci, Ruminant Dis Res Ctr, 88 Wenhua E Rd, Jinan 250014, Peoples R China
Wang, Hongmei
Hou, Peili
论文数: 0引用数: 0
h-index: 0
机构:
Shandong Normal Univ, Coll Life Sci, Ruminant Dis Res Ctr, 88 Wenhua E Rd, Jinan 250014, Peoples R ChinaShandong Normal Univ, Coll Life Sci, Ruminant Dis Res Ctr, 88 Wenhua E Rd, Jinan 250014, Peoples R China
Hou, Peili
He, Hongbin
论文数: 0引用数: 0
h-index: 0
机构:
Shandong Normal Univ, Coll Life Sci, Ruminant Dis Res Ctr, 88 Wenhua E Rd, Jinan 250014, Peoples R ChinaShandong Normal Univ, Coll Life Sci, Ruminant Dis Res Ctr, 88 Wenhua E Rd, Jinan 250014, Peoples R China