Surface impact on nanoparticle-based magnetic resonance imaging contrast agents

被引:165
作者
Zhang, Weizhong [1 ]
Liu, Lin [2 ]
Chen, Hongmin [1 ,3 ]
Hu, Kai [4 ]
Delahunty, Ian [1 ]
Gao, Shi [2 ]
Xie, Jin [1 ,5 ]
机构
[1] Univ Georgia, Dept Chem, Athens, GA 30602 USA
[2] Jilin Univ, China Japan Union Hosp, Dept Nucl Med, 126 Xiantai St, Changchun 13033, Jilin, Peoples R China
[3] Xiamen Univ, Sch Publ Hlth, State Key Lab Mol Vaccinol & Mol Diagnost, Ctr Mol Imaging & Translat Med, Xiamen 361102, Peoples R China
[4] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China
[5] Univ Georgia, Bioimaging Res Ctr, Athens, GA 30602 USA
基金
美国国家卫生研究院; 美国国家科学基金会; 中国国家自然科学基金;
关键词
nanoparticle; magnetic resonance imaging; relaxivity; contrast agents; surface modification; IRON-OXIDE NANOPARTICLES; GADOLINIUM-BASED CONTRAST; METAL-ORGANIC FRAMEWORKS; LARGE-SCALE SYNTHESIS; CARBON QUANTUM DOTS; MRI CONTRAST; FACILE SYNTHESIS; PROSTATE-CANCER; POLYDOPAMINE NANOPARTICLES; BIOMEDICAL APPLICATIONS;
D O I
10.7150/thno.23789
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Magnetic resonance imaging (MRI) is one of the most widely used diagnostic tools in the clinic. To improve imaging quality, MRI contrast agents, which can modulate local T-1 and T-2 relaxation times, are often injected prior to or during MRI scans. However, clinically used contrast agents, including Gd3+-based chelates and iron oxide nanoparticles (IONPs), afford mediocre contrast abilities. To address this issue, there has been extensive research on developing alternative MRI contrast agents with superior r(1) and r(2) relaxivities. These efforts are facilitated by the fast progress in nanotechnology, which allows for preparation of magnetic nanoparticles (NPs) with varied size, shape, crystallinity, and composition. Studies suggest that surface coatings can also largely affect T-1 and T-2 relaxations and can be tailored in favor of a high r(1) or r(2). However, the surface impact of NPs has been less emphasized. Herein, we review recent progress on developing NP-based T-1 and T-2 contrast agents, with a focus on the surface impact.
引用
收藏
页码:2521 / 2548
页数:28
相关论文
共 255 条
[1]   Potential dual imaging nanoparticle: Gd2O3 nanoparticle [J].
Ahmad, Md. Wasi ;
Xu, Wenlong ;
Kim, Sung June ;
Baeck, Jong Su ;
Chang, Yongmin ;
Bae, Ji Eun ;
Chae, Kwon Seok ;
Park, Ji Ae ;
Kim, Tae Jeong ;
Lee, Gang Ho .
SCIENTIFIC REPORTS, 2015, 5
[2]   [Gd-AAZTA]-:: A new structural entry for an improved generation of MRI contrast agents [J].
Aime, S ;
Calabi, L ;
Cavallotti, C ;
Gianolio, E ;
Giovenzana, GB ;
Losi, P ;
Maiocchi, A ;
Palmisano, G ;
Sisti, M .
INORGANIC CHEMISTRY, 2004, 43 (24) :7588-7590
[3]  
Aime S, 2002, ANGEW CHEM INT EDIT, V41, P1017, DOI 10.1002/1521-3773(20020315)41:6<1017::AID-ANIE1017>3.0.CO
[4]  
2-P
[5]   Biodistribution of Gadolinium-Based Contrast Agents, Including Gadolinium Deposition [J].
Aime, Silvio ;
Caravan, Peter .
JOURNAL OF MAGNETIC RESONANCE IMAGING, 2009, 30 (06) :1259-1267
[6]  
Ananta JS, 2010, NAT NANOTECHNOL, V5, P815, DOI [10.1038/NNANO.2010.203, 10.1038/nnano.2010.203]
[7]   Estimation of dynamic parameters from NMR relaxation data using the Lipari-Szabo model-free approach and Bayesian statistical methods [J].
Andrec, M ;
Montelione, GT ;
Levy, RM .
JOURNAL OF MAGNETIC RESONANCE, 1999, 139 (02) :408-421
[8]   What We Can Really Do with Bioresponsive MRI Contrast Agents [J].
Angelovski, Goran .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2016, 55 (25) :7038-7046
[9]  
[Anonymous], 2017, DANISH MED B
[10]   Bioinspired Synthesis and Characterization of Gadolinium-Labeled Magnetite Nanoparticles for Dual Contrast T1- and T2-Weighted Magnetic Resonance Imaging [J].
Bae, Ki Hyun ;
Kim, Young Beom ;
Lee, Yuhan ;
Hwang, JinYoung ;
Park, HyunWook ;
Park, Tae Gwan .
BIOCONJUGATE CHEMISTRY, 2010, 21 (03) :505-512