Association Between Thyroid Nodules and Volume and Metabolic Syndrome in an Iodine-Adequate Area: A Large Community-Based Population Study

被引:28
作者
Su, Yue [1 ,2 ,3 ]
Zhang, Yan-ling [4 ]
Zhao, Meng [1 ,2 ,3 ]
Zhang, Hai-qing [1 ,2 ,3 ]
Zhang, Xu [1 ,2 ,3 ]
Guan, Qing-bo [1 ,2 ,3 ]
Yu, Chun-xiao [2 ,3 ]
Shao, Shan-shan [1 ,2 ,3 ]
Xu, Jin [1 ,2 ,3 ]
机构
[1] Shandong Univ, Shandong Prov Hosp, Dept Endocrinol, 324 Jing 5 Rd, Jinan 250021, Shandong, Peoples R China
[2] Shandong Acad Clin Med, Inst Endocrinol & Metab, Jinan, Shandong, Peoples R China
[3] Shandong Clin Med Ctr Endocrinol & Metab, Jinan, Shandong, Peoples R China
[4] Yishui Cent Hosp, Dept Endocrinol & Metab, Yishui, Peoples R China
基金
中国国家自然科学基金;
关键词
thyroid nodule; thyroid volume; metabolic syndrome; high-density lipoprotein cholesterol; waist circumference; INSULIN-RESISTANCE; PREVALENCE; MODERATE; IODIZATION; GOITER; GLAND;
D O I
10.1089/met.2018.0094
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Background: Given its high incidence, thyroid nodule (TN) warrants public attention. Thyroid volume (TV) has also been associated with multiple factors, such as iodine deficiency and supply and body mass index. It is well known that metabolic syndrome (MetS) comprises many metabolic disturbances, with insulin resistance being its major component. Materials and Methods: The aim of this study was to investigate the relationship between TN and TV and MetS and its components in an iodine-adequate area in Asia. All participants were asked to complete a questionnaire. After excluding 938 individuals based on the exclusion criteria, we reviewed data from 927 of 1865 participants. Adopting MetS diagnostic criteria, we found 437 subjects to be MetS positive [MetS(+)] and 490 subjects to be MetS negative [MetS(-)], respectively. Multivariate linear regression was used to assess the relationship between TNs and MetS. Moreover, univariate binary logistic regression analyses were used to calculate odds ratios (ORs), and 95% confidence intervals (CIs) were used to estimate the associations between different variables and TNs. Results: A total of 232 females and 205 males were MetS(+), as diagnosed using the International Diabetes Federation criteria. However, there were 330 females and 160 males in the group of MetS(-) individuals. The prevalence of TNs was 38.29% in the MetS(+) group and 17.79% in the MetS(-) group. After adjusting for systolic blood pressure, diastolic blood pressure, and gender, only high-density lipoprotein, waist circumference (WC), and age were related to TNs (OR = 0.45, 95% CI 0.27-0.75, P = 0.0023; OR = 1.04, 95% CI 1.02-1.06, P = 0.0036). The TV of all participants was 13.98 (11.24, 17.01) mL; 13.26 (10.62, 16.17) mL for females and 14.96 (11.83, 18.01) mL for males. It was found that only WC was related to TV, after controlling for sex and age (P = 0.02). Conclusions: The morbidity among TN patients in the MetS(+) group was higher than that among the MetS(-) group. High-density lipoprotein cholesterol emerged as a protective factor, and WC was a risk factor for TN. Moreover, TV was related to MetS, and WC was an independent risk factor for TV.
引用
收藏
页码:217 / 222
页数:6
相关论文
共 50 条
[41]   Association between metabolic syndrome and stroke: a population based cohort study [J].
Amir Moghadam-Ahmadi ;
Narjes Soltani ;
Fatemeh Ayoobi ;
Zahra Jamali ;
Tabandeh Sadeghi ;
Nazanin Jalali ;
Alireza Vakilian ;
Mohammad Amin Lotfi ;
Parvin khalili .
BMC Endocrine Disorders, 23
[42]   Association between Urinary Iodine Concentration and Thyroid Nodules in Adults: A Cross-Sectional Study in China [J].
Sun, Hui ;
Wang, Hanyu ;
Lian, Xiaolan ;
Liu, Chao ;
Shi, Bingyin ;
Shi, Lixin ;
Tong, Nanwei ;
Wang, Shu ;
Weng, Jianping ;
Zhao, Jiajun ;
Zhang, Jiaoyue ;
Zheng, Juan ;
Hu, Xiang ;
Tu, Yunxia ;
Yu, Li ;
Shan, Zhongyan ;
Teng, Weiping ;
Chen, Lulu .
BIOMED RESEARCH INTERNATIONAL, 2020, 2020
[43]   A population-based study investigating the association between metabolic syndrome and hepatitis B/C infection (Keelung Community-based Integrated Screening Study No. 10) [J].
Jan, CF ;
Chen, CJ ;
Chiu, YH ;
Chen, LS ;
Wu, HM ;
Huang, CC ;
Yen, MF ;
Chen, THH .
INTERNATIONAL JOURNAL OF OBESITY, 2006, 30 (05) :794-799
[44]   A population-based study investigating the association between metabolic syndrome and Hepatitis B/C infection (Keelung Community-based Integrated Screening Study No. 10) [J].
C-F Jan ;
C-J Chen ;
Y-H Chiu ;
L-S Chen ;
H-M Wu ;
C-C Huang ;
M-F Yen ;
T H-H Chen .
International Journal of Obesity, 2006, 30 :794-799
[45]   Association Between Eating Speed and Metabolic Syndrome in a Three-Year Population-Based Cohort Study [J].
Zhu, Bing ;
Haruyama, Yasuo ;
Muto, Takashi ;
Yamazaki, Takako .
JOURNAL OF EPIDEMIOLOGY, 2015, 25 (04) :332-336
[46]   Metabolic syndrome and inflammatory biomarkers: a community-based cross-sectional study at the Framingham Heart Study [J].
Dallmeier, Dhayana ;
Larson, Martin G. ;
Vasan, Ramachandran S. ;
Keaney, John F., Jr. ;
Fontes, Joao D. ;
Meigs, James B. ;
Fox, Caroline S. ;
Benjamin, Emelia J. .
DIABETOLOGY & METABOLIC SYNDROME, 2012, 4
[47]   Association Between Worse Metabolic Control and Increased Thyroid Volume and Nodular Disease in Elderly Adults with Metabolic Syndrome [J].
Blanc, Evelyn ;
Ponce, Cecilia ;
Brodschi, Dafne ;
Nepote, Alejandra ;
Barreto, Adriana ;
Schnitman, Marta ;
Fossati, Pia ;
Salgado, Pablo ;
Cejas, Claudia ;
Faingold, Cristina ;
Musso, Carla ;
Brenta, Gabriela .
METABOLIC SYNDROME AND RELATED DISORDERS, 2015, 13 (05) :221-226
[48]   Association and functional study between ADIPOQ and metabolic syndrome in elderly Chinese Han population [J].
Wang, Qiao ;
Ren, Decheng ;
Bi, Yan ;
Yuan, Ruixue ;
Li, Dong ;
Wang, Jianying ;
Wang, Ruirui ;
Zhang, Lei ;
He, Guang ;
Liu, Baocheng .
AGING-US, 2020, 12 (24) :25819-25827
[49]   Association Study between Ghrelin Gene Polymorphism and Metabolic Syndrome in a Han Chinese Population [J].
You, Yueyue ;
Yu, Yaqin ;
Wu, Yanhua ;
Rao, Wenwang ;
Zhang, Yangyu ;
Liu, Yingyu ;
Yang, Guang ;
Fu, Yingli ;
Shi, Jieping ;
Kou, Changgui .
CLINICAL LABORATORY, 2017, 63 (01) :175-181
[50]   Gender-Specific Associations Between Metabolic Disorders and Thyroid Nodules: A Cross-Sectional Population-Based Study from China [J].
Zhang, Fan ;
Teng, Di ;
Tong, Nanwei ;
Wang, Guixia ;
Li, Yongze ;
Yu, Xiaohui ;
Shan, Zhongyan ;
Teng, Weiping .
THYROID, 2022, 32 (05) :571-580