Selective C4-F bond cleavage/C-O bond formation of polyfluoroarenes with phenols and benzyl alcohols

被引：20

作者：

Liu, Cuibo ^{[1
,2
]}

Cao, Liming ^{[1
,2
]}

Yin, Xuguang ^{[1
,2
]}

Xu, Haolan ^{[3
]}

Zhang, Bin ^{[1
,2
]}

机构：

[1] Tianjin Univ, Coinnovat Ctr Chem & Chemcial Engn Tianjin, Sch Sci, Dept Chem, Tianjin 300072, Peoples R China

[2] Minist Educ, Key Lab Syst Bioengn, Tianjin 300072, Peoples R China

[3] Univ S Australia, Ian Work Res Inst, Mawson Lakes, SA 5095, Australia

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2013年 / 156卷

基金：

中国国家自然科学基金;

关键词：

Polyfluoroarenes; C-F bond cleavage; C-O bond formation; Phenols; Benzyl alcohols; C-H BOND; COPPER-CATALYZED ARYLATION; ULLMANN-TYPE SYNTHESIS; ARYL HALIDES; F ACTIVATION; LIGAND-FREE; DIARYL ETHER; N-ARYLATION; FLUORINE; EFFICIENT;

D O I：

10.1016/j.jfluchem.2013.08.013

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A facile and efficient SNAr method for the synthesis of unsymmetrical polyfluoroaryl ethers via selective C4-F bond cleavage of pentafluorobenzene is reported. The reaction could proceed smoothly without the requirement of additional metals or ligands, and afford a series of the corresponding products in good to high yields. A wide variety of substituted phenols and alcohols provided 1,2,4,5-tetrafluoropheny ether derivatives in regioselective manner. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：51 / 60

页数：10

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