Nickel trafficking system responsible for urease maturation in Helicobacter pylori

被引：22
作者：
Ge, Rui-Guang [1 ,2 ]
Wang, Dong-Xian [1 ,2 ,3 ]
Hao, Ming-Cong [1 ,2 ]
Sun, Xue-Song [4 ]
机构：
[1] Sun Yat Sen Univ, Key Lab Gene Engn, Minist Educ, Guangzhou 510275, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Coll Life Sci, State Key Lab Biocontrol, Guangzhou 510275, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Affiliated Hosp 1, Lab Prote, Guangzhou 510080, Guangdong, Peoples R China
[4] Jinan Univ, Guangdong Higher Educ Inst, Key Lab Funct Prot Res, Inst Life & Hlth Engn,Coll Life Sci & Technol, Guangzhou 510632, Guangdong, Peoples R China
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2013年 / 19卷 / 45期
基金：
中国国家自然科学基金;
关键词：
Urease; Histidine-rich protein; NikR; NixA; Helicobacter pylori; HISTIDINE-RICH PROTEIN; ALLELIC EXCHANGE MUTAGENESIS; METAL-BINDING SITES; ESCHERICHIA-COLI; DNA-BINDING; ACCESSORY PROTEIN; IN-VITRO; CRYSTAL-STRUCTURES; ACID RESISTANCE; NEGATIVE MUTANT;
D O I：
10.3748/wjg.v19.i45.8211
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Helicobacter pylori (H. pylori) is a common human pathogen responsible for various gastric diseases. This bacterium relies on the production of urease and hydrogenase to inhabit the acidic environment of the stomach. Nickel is an essential cofactor for urease and hydrogenase. H. pylori has to uptake sufficient nickel ions for the maturation of urease, and on the other way, to prevent the toxic effects of excessive nickel ions. Therefore, H. pylori has to strike a delicate balance between the import of nickel ions, its efficient intracellular storage, and delivery to nickel-dependent metalloenzymes when required. The assembly and maturation of the urease enzyme is a complex and timely ordered process, requiring various regulatory, uptake, chaperone and accessory proteins. In this review, we focus on several nickel trafficking proteins involved in urease maturation: NikR, NixA, HypAB, UreEFGH, HspA, Hpn and Hpnl. The work will deepen our understanding of how this pathogenic bacterium adapts to severe habitant environments in the host. (C) 2013 Baishideng Publishing Group Co., Limited. All rights reserved.
引用
收藏
页码：8211 / 8218
页数：8
相关论文
共 89 条
[1]   The metal- and DNA-binding activities of Helicobacter pylori NikR [J].
Abraham, Lihor O. ;
Li, Yanjie ;
Zamble, Deborah B. .
JOURNAL OF INORGANIC BIOCHEMISTRY, 2006, 100 (5-6) :1005-1014
[2]   INABILITY OF AN ISOGENIC UREASE-NEGATIVE MUTANT STRAIN OF HELICOBACTER-MUSTELAE TO COLONIZE THE FERRET STOMACH [J].
ANDRUTIS, KA ;
FOX, JG ;
SCHAUER, DB ;
MARINI, RP ;
MURPHY, JC ;
YAN, LL ;
SOLNICK, JV .
INFECTION AND IMMUNITY, 1995, 63 (09) :3722-3725
[3]   Escherichia coli HypA is a zinc metalloprotein with a weak affinity for nickel [J].
Atanassova, A ;
Zamble, DB .
JOURNAL OF BACTERIOLOGY, 2005, 187 (14) :4689-4697
[4]   Crystallographic and X-ray absorption spectroscopic characterization of Helicobacter pylori UreE bound to Ni2+ and Zn2+ reveals a role for the disordered C-terminal arm in metal trafficking [J].
Banaszak, Katarzyna ;
Martin-Diaconescu, Vlad ;
Bellucci, Matteo ;
Zambelli, Barbara ;
Rypniewski, Wojciech ;
Maroney, Michael J. ;
Ciurli, Stefano .
BIOCHEMICAL JOURNAL, 2012, 441 :1017-1026
[5]   Allelic exchange mutagenesis of nixA in Helicobacter pylori results in reduced nickel transport and urease activity [J].
Bauerfeind, P ;
Garner, RM ;
Mobley, HLT .
INFECTION AND IMMUNITY, 1996, 64 (07) :2877-2880
[6]   Helicobacter pylori UreE, a urease accessory protein: specific Ni2+- and Zn2+-binding properties and interaction with its cognate UreG [J].
Bellucci, Matteo ;
Zambelli, Barbara ;
Musiani, Francesco ;
Turano, Paola ;
Ciurli, Stefano .
BIOCHEMICAL JOURNAL, 2009, 422 :91-100
[7]   Holo-Ni2+ Helicobacter pylori NikR contains four square-planar nickel-binding sites at physiological pH [J].
Benini, Stefano ;
Cianci, Michele ;
Ciurli, Stefano .
DALTON TRANSACTIONS, 2011, 40 (31) :7831-7833
[8]   Dependence of Helicobacter pylori urease activity on the nickel-sequestering ability of the UreE accessory protein [J].
Benoit, S ;
Maier, RJ .
JOURNAL OF BACTERIOLOGY, 2003, 185 (16) :4787-4795
[9]   Interaction between the Helicobacter pylori accessory proteins HypA and UreE is needed for urease maturation [J].
Benoit, Stephane L. ;
Mehta, Nalini ;
Weinberg, Michael V. ;
Maier, Cheryl ;
Maier, Robert J. .
MICROBIOLOGY-SGM, 2007, 153 :1474-1482
[10]   Helicobacter pylori Stores Nickel To Aid Its Host Colonization [J].
Benoit, Stephane L. ;
Miller, Erica F. ;
Maier, Robert J. .
INFECTION AND IMMUNITY, 2013, 81 (02) :580-584
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