Secondary CD5+Diffuse Large B-Cell Lymphoma Not Associated With Transformation of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (Richter Syndrome)

被引：13

作者：

Maeshima, Akiko Miyagi ^{[1
]}

Taniguchi, Hirokazu

Nomoto, Junko ^{[2
]}

Maruyama, Dai ^{[2
]}

Kim, Sung-Won ^{[2
]}

Watanabe, Takashi ^{[2
]}

Kobayashi, Yukio ^{[2
]}

Tobinai, Kensei ^{[2
]}

Matsuno, Yoshihiro ^{[3
]}

机构：

[1] Natl Canc Ctr, Clin Lab Div, Chuo Ku, Tokyo 1040045, Japan

[2] Natl Canc Ctr, Hematol & Stem Cell Transplantat Div, Tokyo 1040045, Japan

[3] Hokkaido Univ Hosp, Dept Surg Pathol, Sapporo, Hokkaido 060, Japan

来源：

AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2009年 / 131卷 / 03期

关键词：

CD5; Diffuse large B-cell lymphoma; Secondary disease; Immunohistochemistry; Non-Richter syndrome; FOLLICULAR LYMPHOMA; CD5+;

D O I：

10.1309/AJCP58FETFGLCKKW

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Few cases of secondary CD5+ diffuse large B-cell lymphoma (DLBCL) that are not Richter syndrome have been reported previously. We report 9 cases of non-Richter syndrome secondary CD5+ DLBCL. Among 529 cases of DLBCL, 38 (7.2%) were CD5+ DLBCL, including 9 of secondary CD5+ DLBCL. Five cases gained CD5 expression during the clinical course of DLBCL (group 1). Three cases showed transformation from CD5-low-grade B-cell lymphoma to CD5+ DLBCL (group 2). The remaining case showed coexistence of CD5+ DLBCL and CD5+ follicular lymphoma. The clonal relationships of CD5- and CD5+ tumors were confirmed in all 4 available cases. Cases of secondary CD5+ DLBCL that were not Richter syndrome were classifiable into 3 groups. Groups I and 2 showed the gain of CD5 during the clinical course or transformation of the tumors, suggesting that CD5 expression is closely associated with the progression of B-cell lymphoma.

引用

页码：339 / 346

页数：8

共 21 条

[21] De novo CD5+ diffuse large B-cell lymphoma:: a clinicopathologic study of 109 patients
Yamaguchi, M
Seto, M
Okamoto, M
Ichinohasama, R
Nakamura, N
Yoshino, T
Suzumiya, J
Murase, T
Miura, I
Akasaka, T
Tamaru, J
Suzuki, R
Kagami, Y
Hirano, M
Morishima, Y
Ueda, R
Shiku, H
Nakamura, S
[J]. BLOOD, 2002, 99 (03) : 815 - 821

← 1 2 3 →