IL-10, TNF-α & IFN-γ: Potential early biomarkers for preeclampsia

The present study was designed to evaluate levels of IL4, IL10, TNF-alpha & IFN-gamma at early second trimester and 24 h from delivery to assess potential correlation of cytokine variation with preeclampsia. A total of 176 consecutive healthy, normotensive primigravidas with uncomplicated singleton pregnancies were recruited at 14-18 weeks of gestation. Serum cytokine levels were estimated at recruitment and 24 h from delivery. In present study, 14(7.95%) women developed preeclampsia. Levels of IL-10, TNF-alpha and IFN-gamma (Mean +/- SE) at recruitment were statistically significantly lower in preeclamptic group (39.21 +/- 9.46 pg/mL, 73.57 +/- 13.37 pg/mL and 0.70 +/- 0.20 pg/mL, respectively) than non-preeclamptic group (86.02 +/- 4.55 pg/mL, 601.37 +/- 63.54 pg/mL and 1.67 +/- 0.08 pg/mL, respectively) (p < 0.05). In preeclamptic group, IL-4 and TNF-alpha levels (Mean +/- SE) were significantly higher 24 h from delivery (5.35 +/- 0.95 pg/mL and 381.21 +/- 43.28 pg/mL, respectively) than at recruitment (2.39 +/- 0.71 pg/mL and 73.57 +/- 13.37 pg/mL) (p = 0.019 and 0.0001, respectively) while IL-10 and IFN-gamma levels decreased after delivery but the change was not statistically significant. Therefore, the levels of IL-10, TNF-alpha and IFN-gamma between 14 and 18 weeks of gestation may act as potential early biomarkers in the diagnosis of preeclampsia. (C) 2013 Elsevier Inc. All rights reserved.