TRP Channels and Pain

被引:884
作者
Julius, David [1 ]
机构
[1] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94158 USA
来源
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 29 | 2013年 / 29卷
关键词
somatosensation; nociception; thermosensation; inflammatory pain; natural products; analgesics; SPECIES-SPECIFIC SENSITIVITY; RECEPTOR POTENTIAL CHANNELS; ACTIVATED ION-CHANNEL; COLD SENSOR TRPM8; CAPSAICIN RECEPTOR; VANILLOID RECEPTOR; NEUROGENIC INFLAMMATION; NOCICEPTIVE NEURONS; MOLECULAR-BASIS; PHOSPHOLIPASE-C;
D O I
10.1146/annurev-cellbio-101011-155833
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Nociception is the process whereby primary afferent nerve fibers of the somatosensory system detect noxious stimuli. Pungent irritants from pepper, mint, and mustard plants have served as powerful pharmacological tools for identifying molecules and mechanisms underlying this initial step of pain sensation. These natural products have revealed three members of the transient receptor potential (TRP) ion channel family-TRPV1, TRPM8, and TRPA1-as molecular detectors of thermal and chemical stimuli that activate sensory neurons to produce acute or persistent pain. Analysis of TRP channel function and expression has validated the existence of nociceptors as a specialized group of somatosensory neurons devoted to the detection of noxious stimuli. These studies are also providing insight into the coding logic of nociception and how specification of nociceptor subtypes underlies behavioral discrimination of noxious thermal, chemical, and mechanical stimuli. Biophysical and pharmacological characterization of these channels has provided the intellectual and technical foundation for developing new classes of analgesic drugs.
引用
收藏
页码:355 / 384
页数:30
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