A Randomized Phase III Trial Exploring the Prognostic Value of Extensive Intraoperative Peritoneal Lavage in Addition to Standard Treatment for Resectable Advanced Gastric Cancer: CCOG 1102 Study

被引：21

作者：

Misawa, Kazunari ^{[1
]}

Mochizuki, Yoshinari ^{[2
]}

Ohashi, Norifumi ^{[3
]}

Matsui, Takanori ^{[4
]}

Nakayama, Hiroshi ^{[5
]}

Tsuboi, Kenji ^{[6
]}

Sakai, Mitsuru ^{[7
]}

Ito, Seiji ^{[1
]}

Morita, Satoshi ^{[8
]}

Kodera, Yasuhiro ^{[9
]}

机构：

[1] Aichi Canc Ctr Hosp, Dept Surg Gastroenterol, Nagoya, Aichi 4648681, Japan

[2] Komaki Municipal Hosp, Dept Surg, Komaki, Japan

[3] Aichi Med Univ, Dept Surg Gastroenterol, Nagakute, Aichi 48011, Japan

[4] Aichi Hosp, Dept Surg Gastroenterol, Aichi Canc Ctr, Okazaki, Aichi, Japan

[5] Nagoya Med Ctr, Dept Surg, Nagoya, Aichi, Japan

[6] Tosei Gen Hosp, Dept Surg, Seto, Japan

[7] Ichinomiya Municipal Hosp, Dept Surg, Ichinomiya, Japan

[8] Yokohama City Univ, Grad Sch Med, Dept Biostat & Epidemiol, Yokohama, Kanagawa 232, Japan

[9] Nagoya Univ, Grad Sch Med, Dept Gastroenterol Surg Surg 2, Nagoya, Aichi 4648601, Japan

来源：

JAPANESE JOURNAL OF CLINICAL ONCOLOGY | 2014年 / 44卷 / 01期

关键词：

gastric cancer; gastrectomy; peritoneal lavage; clinical trial; Phase III; RECURRENCE;

D O I：

10.1093/jjco/hyt157

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A randomized controlled trial has started in Japan to evaluate the efficacy of extensive intraoperative peritoneal lavage in the treatment of resectable advanced gastric cancer. Patients with T3 or deeper carcinoma of the stomach are intraoperatively randomized to either extensive intraoperative peritoneal lavage arm or extensive intraoperative peritoneal lavage arm. A total of 300 patients will be accrued from 20 institutions. The primary endpoint is disease-free survival, and secondary end-points are overall survival, peritoneal recurrence-free survival and incidence of adverse events.

引用

页码：101 / 103

页数：3

共 8 条

[1] Japanese classification of gastric carcinoma: 3rd English edition [J].

Sano T. ;

Kodera Y. .

GASTRIC CANCER, 2011, 14 (02) :101-112

[2] Japanese gastric cancer treatment guidelines 2010 (ver. 3) [J].

Sano T. ;

Kodera Y. .

GASTRIC CANCER, 2011, 14 (02) :113-123

[3]

Kodera Y, 1998, INT J CANCER, V79, P429, DOI 10.1002/(SICI)1097-0215(19980821)79:4<429::AID-IJC20>3.0.CO

[4]

2-Z

[5] Extensive Intraoperative Peritoneal Lavage as a Standard Prophylactic Strategy for Peritoneal Recurrence in Patients with Gastric Carcinoma [J].

Kuramoto, Masafumi ;

Shimada, Shinya ;

Ikeshima, Satosi ;

Matsuo, Akinobu ;

Yagi, Yasushi ;

Matsuda, Masakazu ;

Yonemura, Yutaka ;

Baba, Hideo .

ANNALS OF SURGERY, 2009, 250 (02) :242-246

[6] Randomized trial of adjuvant chemotherapy with mitomycin, fluorouracil, and cytosine arabinoside followed by oral fluorouracil in serosa-negative gastric cancer: Japan Clinical Oncology Group 9206-1 [J].

Nashimoto, A ;

Nakajima, T ;

Furukawa, H ;

Kitamura, M ;

Kinoshita, T ;

Yamamura, Y ;

Sasako, M ;

Kunii, Y ;

Motohashi, H ;

Yamamoto, S .

JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (12) :2282-2287

[7] D2 lymphadenectomy alone or with para-aortic nodal dissection for gastric cancer [J].

Sasako, Mitsuru ;

Sano, Takeshi ;

Yamamoto, Seiichiro ;

Kurokawa, Yukinori ;

Nashimoto, Atsushi ;

Kurita, Akira ;

Hiratsuka, Masahiro ;

Tsujinaka, Toshimasa ;

Kinoshita, Taira ;

Arai, Kuniyoshi ;

Yamamura, Yoshitaka ;

Okajima, Kunio .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (05) :453-462

[8] Recurrence following curative resection for gastric carcinoma [J].

Yoo, CH ;

Noh, SH ;

Shin, DW ;

Choi, SH ;

Min, JS .

BRITISH JOURNAL OF SURGERY, 2000, 87 (02) :236-242

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