Platelet aggregation and TGF-beta1 plasma levels in pregnant women with preeclampsia

被引:59
作者
Serrao Peracoli, Maria Terezinha [1 ]
Ferreira Menegon, Fernanda Tereza [2 ]
Medeiros Borges, Vera Therezinha [2 ]
de Araujo Costa, Roberto Antonio [2 ]
Thomazini-Santos, Izolete Aparecida [3 ]
Peracoli, Jose Carlos [2 ]
机构
[1] Sao Paulo State Univ, Botucatu Med Sch, Inst Biosci, Dept Microbiol & Immunol, BR-18618970 Botucatu, SP, Brazil
[2] Sao Paulo State Univ, Botucatu Med Sch, Dept Obstet & Gynaecol, BR-18618970 Botucatu, SP, Brazil
[3] Sao Paulo State Univ, Botucatu Med Sch, Haemostasy Lab Clin Hosp, BR-18618970 Botucatu, SP, Brazil
基金
巴西圣保罗研究基金会;
关键词
Platelets; TGF-beta(1); Preeclampsia; Pregnancy;
D O I
10.1016/j.jri.2008.08.001
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Objectives: Platelets and transforming growth factor-beta(1) (TGF-beta(1)) are thought to be involved in the pathogenesis of preeclampsia. Our objectives were to determine plasma concentration of TGF-beta(1) in normotensive and preeclamptic women in the third trimester of pregnancy and to evaluate the correlation of TGF-beta(1) plasma levels with platelet count and agonist-induced aggregation capacity. Methods: Thirty-three women with preeclampsia were compared with 36 healthy women with uncomplicated pregnancies. Peripheral venous blood samples were obtained, and TGF-beta(1) plasma levels measured by an enzyme-linked immunoassay. Platelet aggregation was induced by the agonist agents adenosine diphosphate (ADP), collagen and epinephrine, and was determined in platelet-rich plasma by aggregometry. Results: Plasma concentrations of active TGF-beta(1) were significantly higher in preeclamptic women (10.41 +/- 2.07 ng/mL) compared with normotensive pregnant women (7.01 +/- 3.29 ng/mL). Platelet number and platelet agonist-induced aggregation percent were significantly lower in patients with precclampsia than in healthy pregnant women. A significant correlation was observed between TGF-beta(1) plasma levels and platelet agonist-induced aggregation percent as between plasma levels of TGF-beta(1) and platelet number in preeclamptic patients. Conclusion: The association between impairment in platelet responsiveness and higher levels of TGF-beta(1) in the plasma of patients with preeclampsia suggests that this cytokine may play a role in the pathophysiological events of preeclampsia that are dependent on platelet activation. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:79 / 84
页数:6
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