Voltage-coupled conformational dynamics of mitochondrial protein-import channel

被引：7

作者：

van der Laan, Martin ^{[1
,2
]}

Schrempp, Sandra G. ^{[1
,2
,3
]}

Pfanner, Nikolaus ^{[1
,2
]}

机构：

[1] Univ Freiburg, Inst Biochem & Mol Biol, Zentrum Biochem & Mol Zellforsch, D-79106 Freiburg, Germany

[2] Univ Freiburg, BIOSS Ctr Biol Signalling Studies, D-79106 Freiburg, Germany

[3] Univ Freiburg, Fak Biol, D-79106 Freiburg, Germany

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2013年 / 20卷 / 08期

关键词：

TIM23; COMPLEX; PRESEQUENCE TRANSLOCASE; INNER MEMBRANE; TIM50; PREPROTEINS; RECEPTOR; REVEALS; OUTER;

D O I：

10.1038/nsmb.2643

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria contain multisubunit translocases to import preproteins from the cytosol. The presequence translocase of the inner membrane operates in a voltage-gated manner, but how a preprotein-conducting channel responds to the membrane potential was unknown. A new study identifies a voltage-coupled conformational change in a transmembrane segment of the Tim23 import channel, representing a major step toward understanding the molecular basis of a voltage-gated protein translocase.

引用

页码：915 / 917

页数：3