Voltage-coupled conformational dynamics of mitochondrial protein-import channel

被引：7
|
作者：
van der Laan, Martin [1 ,2 ]
Schrempp, Sandra G. [1 ,2 ,3 ]
Pfanner, Nikolaus [1 ,2 ]
机构：
[1] Univ Freiburg, Inst Biochem & Mol Biol, Zentrum Biochem & Mol Zellforsch, D-79106 Freiburg, Germany
[2] Univ Freiburg, BIOSS Ctr Biol Signalling Studies, D-79106 Freiburg, Germany
[3] Univ Freiburg, Fak Biol, D-79106 Freiburg, Germany
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2013年 / 20卷 / 08期
关键词：
TIM23; COMPLEX; PRESEQUENCE TRANSLOCASE; INNER MEMBRANE; TIM50; PREPROTEINS; RECEPTOR; REVEALS; OUTER;
D O I：
10.1038/nsmb.2643
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mitochondria contain multisubunit translocases to import preproteins from the cytosol. The presequence translocase of the inner membrane operates in a voltage-gated manner, but how a preprotein-conducting channel responds to the membrane potential was unknown. A new study identifies a voltage-coupled conformational change in a transmembrane segment of the Tim23 import channel, representing a major step toward understanding the molecular basis of a voltage-gated protein translocase.
引用
收藏
页码：915 / 917
页数：3
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