Enzymatic resolution of secondary alcohols coupled with ruthenium-catalyzed racemization without hydrogen mediator

被引：90
作者：
Koh, JH
Jung, HM
Kim, MJ
Park, J
机构：
[1] Pohang Univ Sci & Technol, Dept Chem, Pohang 790784, South Korea
[2] Pohang Univ Sci & Technol, Ctr Biofunct Mol, Pohang 790784, South Korea
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 34期
关键词：
D O I：
10.1016/S0040-4039(99)01237-X
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
(eta(5)-Indenyl)RuCl(PPh3)(2) was found to catalyze the racemization of secondary alcohols in the presence of triethylamine and oxygen. Unlike previously reported metal-catalyzed racemizations, ketones were not required as hydrogen mediators in our process. The Ru-catalyzed racemization was coupled with enzymatic acetylation for the dynamic kinetic resolution of secondary alcohols to give chiral acetates in good yields (60-98%) with high enantioselectivities (82-99% ee). (C) 1999 Elsevier Science Ltd. All rights reserved.
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页码：6281 / 6284
页数：4
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