Programmed Selective sp2 C-O Bond Activation toward Multiarylated Benzenes

被引：54

作者：

Zhao, Fei ^{[1
,2
]}

Zhang, Yun-Fei ^{[4
]}

Wen, Jing ^{[5
]}

Yu, Da-Gang ^{[1
,2
]}

Wei, Jiang-Bo ^{[1
,2
]}

Xi, Zhenfeng ^{[1
,2
,3
]}

Shi, Zhang-Jie ^{[1
,2
,3
]}

机构：

[1] Peking Univ, Coll Chem, Minist Educ, BNLMS, Beijing 100871, Peoples R China

[2] Peking Univ, Coll Chem, Minist Educ, Key Lab Bioorgan Chem & Mol Engn, Beijing 100871, Peoples R China

[3] Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

[4] China Agr Univ, Dept Chem, Beijing 100094, Peoples R China

[5] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Gansu, Peoples R China

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 13期

关键词：

CROSS-COUPLING REACTIONS; CARBON-CARBON BONDS; SUZUKI-MIYAURA; GRIGNARD-REAGENTS; STEREOCONTROLLED SYNTHESIS; BIOLOGICAL EVALUATION; BIARYL CONSTRUCTION; EFFICIENT SYNTHESIS; SYNTHETIC METHODS; DIRECT ARYLATION;

D O I：

10.1021/ol4011757

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A variety of important multiarylated benzenes were efficiently synthesized from phloroglucinol derivatives 1 through sequential cross-couplings via Pd-catalyzed C-OTs, Ni-catalyzed C-OC(O)NEt2, and C-OMe bond activation. High selectivity was achieved based on the rational design and inherent diversity in the reactivity of different C-O bonds.

引用

页码：3230 / 3233

页数：4

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