Ligands bind to Sortilin in the tunnel of a ten-bladed β-propeller domain

被引：125

作者：

Quistgaard, Esben M. ^{[2
]}

Madsen, Peder ^{[1
]}

Groftehauge, Morten K. ^{[2
]}

Nissen, Poul ^{[2
]}

Petersen, Claus M. ^{[1
]}

Thirup, Soren S. ^{[2
]}

机构：

[1] Univ Aarhus, Inst Med Biochem, MIND Ctr, DK-8000 Aarhus C, Denmark

[2] Univ Aarhus, Dept Mol Biol, MIND Ctr, DK-8000 Aarhus C, Denmark

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2009年 / 16卷 / 01期

关键词：

RECEPTOR-ASSOCIATED PROTEIN; SORTILIN/NEUROTENSIN RECEPTOR-3; NEUROTENSIN RECEPTOR; VPS10P DOMAIN; HUMAN BRAIN; CELL-DEATH; COMPLEX; ROLES;

D O I：

10.1038/nsmb.1543

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The structure of the Sortilin ectodomain in complex with neurotensin has been determined at 2-angstrom resolution, revealing that the C-terminal part of neurotensin binds in the tunnel of a ten-bladed beta-propeller domain. Binding competition studies suggest that additional binding sites, for example, for the prodomain of nerve growth factor-beta, are present in the tunnel and that competition for binding relates to the restricted space inside the propeller.

引用

页码：96 / 98

页数：3

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