Ligands bind to Sortilin in the tunnel of a ten-bladed β-propeller domain

被引：125
作者：
Quistgaard, Esben M. [2 ]
Madsen, Peder [1 ]
Groftehauge, Morten K. [2 ]
Nissen, Poul [2 ]
Petersen, Claus M. [1 ]
Thirup, Soren S. [2 ]
机构：
[1] Univ Aarhus, Inst Med Biochem, MIND Ctr, DK-8000 Aarhus C, Denmark
[2] Univ Aarhus, Dept Mol Biol, MIND Ctr, DK-8000 Aarhus C, Denmark
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2009年 / 16卷 / 01期
关键词：
RECEPTOR-ASSOCIATED PROTEIN; SORTILIN/NEUROTENSIN RECEPTOR-3; NEUROTENSIN RECEPTOR; VPS10P DOMAIN; HUMAN BRAIN; CELL-DEATH; COMPLEX; ROLES;
D O I：
10.1038/nsmb.1543
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The structure of the Sortilin ectodomain in complex with neurotensin has been determined at 2-angstrom resolution, revealing that the C-terminal part of neurotensin binds in the tunnel of a ten-bladed beta-propeller domain. Binding competition studies suggest that additional binding sites, for example, for the prodomain of nerve growth factor-beta, are present in the tunnel and that competition for binding relates to the restricted space inside the propeller.
引用
收藏
页码：96 / 98
页数：3
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