Extremely Tight Binding of a Ruthenium Complex to Glycogen Synthase Kinase 3

被引：48

作者：

Atilla-Gokcumen, G. Ekin ^{[1
]}

Pagano, Nicholas ^{[1
]}

Streu, Craig ^{[2
]}

Maksimoska, Jasna ^{[2
]}

Filippakopoulos, Panagis ^{[3
]}

Knapp, Stefan ^{[3
]}

Meggers, Eric ^{[1
]}

机构：

[1] Univ Marburg, Fachbereich Chem, D-35043 Marburg, Germany

[2] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA

[3] Univ Oxford, Botnar Res Ctr, Ctr Struct Genom, Oxford OX3 7LD, England

来源：

CHEMBIOCHEM | 2008年 / 9卷 / 18期

基金：

美国国家卫生研究院;

关键词：

bioorganometallic chemistry; glycogen synthase kinase 3; inhibitors; picomolar binding constant; ruthenium;

D O I：

10.1002/cbic.200800489

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：2933 / 2936

页数：4

共 29 条

[1] Organometallic compounds with biological activity: A very selective and highly potent cellular inhibitor for glycogen synthase kinase 3 [J].

Atilla-Gokcumen, G. Ekin ;

Williams, Douglas S. ;

Bregman, Howard ;

Pagano, Nicholas ;

Meggers, Eric .

CHEMBIOCHEM, 2006, 7 (09) :1443-1450

[2] Structural characterization of the GSK-3β active site using selective and non-selective ATP-mimetic inhibitors [J].

Bertrand, JA ;

Thieffine, S ;

Vulpetti, A ;

Cristiani, C ;

Valsasina, B ;

Knapp, S ;

Kalisz, HM ;

Flocco, M .

JOURNAL OF MOLECULAR BIOLOGY, 2003, 333 (02) :393-407

[3] Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418 [J].

Bhat, R ;

Xue, YF ;

Berg, S ;

Hellberg, S ;

Ormö, M ;

Nilsson, Y ;

Radesäter, AC ;

Jerning, E ;

Markgren, PO ;

Borgegård, T ;

Nylöf, M ;

Giménez-Cassina, A ;

Hernández, F ;

Lucas, JJ ;

Díaz-Nido, J ;

Avila, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (46) :45937-45945

[4] Rapid access to unexplored chemical space by ligand scanning around a ruthenium center: Discovery of potent and selective protein kinase inhibitors [J].

Bregman, H ;

Carroll, PJ ;

Meggers, E .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (03) :877-884

[5] An organometallic inhibitor for glycogen synthase kinase 3 [J].

Bregman, H ;

Williams, DS ;

Atilla, GE ;

Carroll, PJ ;

Meggers, E .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (42) :13594-13595

[6] Ruthenium half-sandwich complexes as protein kinase inhibitors:: An N-succinimidyl ester for rapid derivatizations of the cyclopentadienyl moiety [J].

Bregman, Howard ;

Meggers, Eric .

ORGANIC LETTERS, 2006, 8 (24) :5465-5468

[7] Chemical inhibitors of protein kinases [J].

Bridges, AJ .

CHEMICAL REVIEWS, 2001, 101 (08) :2541-2571

[8] Tyrosine kinase inhibitors .8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor [J].

Bridges, AJ ;

Zhou, H ;

Cody, DR ;

Rewcastle, GW ;

McMichael, A ;

Showalter, HDH ;

Fry, DW ;

Kraker, AJ ;

Denny, WA .

JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (01) :267-276

[9]

CHENG Y, 1973, BIOCHEM PHARMACOL, V22, P3099

[10]

Debreczeni J. E., 2006, ANGEW CHEM, V118, P1610

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