Risk Factors and Laboratory Test Results Associated with Severe Illness and Mortality in COVID-19 Patients: A systematic review

Background: we aimed to systematically review all relevant studies related to the risk factors and laboratory test results associated with severe illness and mortality in COVID-19 patients. Methods: we utilised PubMed, Scopus, ProQuest, Wiley Online Library, ScienceDirect and MedRxiv to search for studies, with additional hand-searched journals. We included systematic reviews/meta-analyses, cohort and case control studies of suspected and/or confirmed COVID-19 cases with severe illness and/or mortality as outcomes. We included laboratory test results and risk factors. We assessed risk of bias using ROBIS-1 and Newcastle-Ottawa Scale assessment tool. Type of study, risk of bias, and precision of results determined evidence sufficiency. Results: of 26 records included, sufficient evidence suggested the association between age >60 years, hypertension, coronary heart disease, DM, serum LDH 250-500 U/L, LDH >500 U/L, and lymphopenia (lymphocyte count <= 1.0x 109/L) and severe illness of COVID-19. CD3+CD8+ cell count <= 75 cell/mu l, D-dimer > 1 mg/L, AKI stage 2 and 3, proteinuria >= 1+, hematuria >= 1+, and peak serum creatinine > 13.26 mu mol/L are associated with mortality. Conclusion: age >60 years, hypertension, DM and coronary heart disease are the risk factors for severe illness ofCOP7D-19. Laboratory test results associated with severe illness are serum LDH 250-500 U/L, LDH >500 U/L, and lymphopenia, whereas test results associated with mortality are CD3+CD8+ cell count <= 75 cell/mu l AKI stage 2 and 3, proteinuria >= 1+, hematuria >= 1+, D-dimer > 1 mg/L, peak serum creatinine > 13.26 mu mol/L.