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Endocrine and clinical effects of myo-inositol administration in polycystic ovary syndrome. A randomized study
被引:93
作者:
Artini, P. G.
[1
]
Di Berardino, O. M.
[1
]
Papini, F.
[1
]
Genazzani, A. D.
[2
]
Simi, G.
[1
]
Ruggiero, M.
[1
]
Cela, V.
[1
]
机构:
[1] Univ Pisa, Div Obstet & Gynecol, Dept Reprod Med & Child Dev, I-56126 Pisa, Italy
[2] Univ Modena, Div Obstet & Gynecol, Dept Reprod Med & Child Dev, I-41100 Modena, Italy
关键词:
Hyperinsulinemia;
inositolphosphoglycan;
myo-inositol;
policystic ovary syndrome;
IN-VITRO MATURATION;
INSULIN-RESISTANCE;
NONOBESE PATIENTS;
WOMEN;
HYPERINSULINEMIA;
HYPERANDROGENISM;
FERTILIZATION;
OOCYTES;
EMBRYOS;
D O I:
10.3109/09513590.2012.743020
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Objective: To evaluate the effects the administration of myo-inositol (MYO) on hormonal parameters in a group of polycystic ovary syndrome (PCOS) patients. Design: Controlled clinical study. Setting: PCOS patients in a clinical research environment. Patients: 50 overweight PCOS patients were enrolled after informed consent. Interventions: All patients underwent hormonal evaluations and an oral glucose tolerance test (OGTT before and after 12 weeks of therapy (Group A (n 1/4 10): MYO 2 g plus folic acid 200 mg every day; Group B (n 1/4 10): folic acid 200 mg every day). Ultrasound examinations and Ferriman-Gallwey score were also performed. Main outcome measures: Plasma LH, FSH, PRL, E2, 17OHP, A, T, glucose, insulin, C peptide concentrations, BMI, HOMA index and glucose-to-insulin ratio. Results: After 12 weeks of MYO administration plasma LH, PRL, T, insulin levels and LH/FSH resulted significantly reduced. Insulin sensitivity, expressed as glucose-to-insulin ratio and HOMA index resulted significantly improved after 12 weeks of treatment. Menstrual cyclicity was restored in all amenorrheic and oligomenorrheic subjects. No changes occurred in the patients treated with folic acid. Conclusions: MYO administration improves reproductive axis functioning in PCOS patients reducing the hyperinsulinemic state that affects LH secretion.
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页码:375 / 379
页数:5
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