Adult Stem Cells in the Human Testis

被引：7

作者：

Goossens, Ellen ^{[1
]}

Tournaye, Herman ^{[2
]}

机构：

[1] Vrije Univ Brussel, Biol Testis BITE, Brussels, Belgium

[2] Ctr Reprod Med, Brussels, Belgium

来源：

SEMINARS IN REPRODUCTIVE MEDICINE | 2013年 / 31卷 / 01期

关键词：

male infertility; spermatogenesis; stem cell; transplantation; PRIMORDIAL GERM-CELLS; HUMAN TESTICULAR TISSUE; LONG-TERM CULTURE; MOUSE TESTES; IN-VITRO; UNDIFFERENTIATED SPERMATOGONIA; SELF-RENEWAL; TRANSGENIC MICE; DIFFERENTIATING SPERMATOGONIA; CRYOPRESERVATION PROTOCOLS;

D O I：

10.1055/s-0032-1331796

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The primary function of the mammalian testis is the production of both gametes and hormones over a reproductive lifespan. This production of gametes proceeds in the seminiferous tubules and is supported by a stem cell population, the spermatogonial stemcells (SSCs). Like other tissue-specific stemcells, SSCs are defined by their ability to balance between self-renewal and differentiation. This balance maintains the stem cell pool and guarantees the daily production of spermatozoa from puberty onward. Studying SSCs is difficult because they are very few in number (0.03% of all germ cells), and specific markers have not been identified so far. Most of our knowledge results from experiments in rodent models. Very little is known about human SSCs. This review provides an update on SSCs, on their role in male fertility, and on (future) clinical applications using these fascinating cells.

引用

页码：39 / 48

页数：10

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