New cytotoxic epidithiodioxopiperazines related to verticillin A from a marine isolate of the fungus Penicillium

被引：55

作者：

Son, BW ^{[1
]}

Jensen, PR ^{[1
]}

Kauffman, CA ^{[1
]}

Fenical, W ^{[1
]}

机构：

[1] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA

来源：

NATURAL PRODUCT LETTERS | 1999年 / 13卷 / 03期

基金：

美国国家科学基金会; 美国国家卫生研究院; 新加坡国家研究基金会;

关键词：

marine fungi; Penicillium sp; cytotoxic dioxopiperazines; epidithio-dioxopiperazine dimers; verticillins;

D O I：

10.1080/10575639908048788

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new cytotoxic dioxopiperazine dimers, 11,11'-dideoxyverticillin A (1) and 11'-deoxyverticillin A (2), and the previously described verticillin A (3), have been isolated from the mycelium of a marine-derived fungus of the genus Penicillium. An inactive, but new bisdethio-bis(methylthio)-dioxopiperazine 4, was also obtained by extraction of the culture broth. The structures and absolute stereochemistries of the new compounds were assigned on the basis of NMR and CD experiments. Compounds 1 and 2 exhibit potent in vitro cytotoxicity against HCT-116 human colon carcinoma (IC50 = 30 ng/ml).

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收藏

页码：213 / 222

页数：10

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