Hepcidin Regulation of Iron Transport

被引：127

作者：

Collins, Janics E. ^{[3
]}

Wessling-Resnick, Marianne ^{[1
,2
]}

Knutson, Mitchell D. ^{[4
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[2] Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA

[3] SUNY Buffalo, Dept Exercise & Nutr Sci, Buffalo, NY 14214 USA

[4] Univ Florida, Dept Food Sci & Human Nutr, Gainesville, FL 32611 USA

来源：

JOURNAL OF NUTRITION | 2008年 / 138卷 / 11期

关键词：

D O I：

10.3945/jn.108.096347

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The discovery of hepcidin as a key regulator of iron homeostasis has advanced our current knowledge of this field. Liver-derived hepcidin peptide is secreted in response to iron and inflammation and interacts with the iron export protein ferroportin. This review summarizes recent advances discussed at the Symposium. A particular focus is on molecular interactions between hepcidin and ferroportin, the regulation of hepcidin expression by iron and inflammation, and emerging methods to measure serum hepcidin in human populations. J. Nutr. 138: 2284-2288, 2008.

引用

页码：2284 / 2288

页数：5

共 48 条

[1] Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression [J].

Babitt, JL ;

Huang, FW ;

Wrighting, DM ;

Xia, Y ;

Sidis, Y ;

Samad, TA ;

Campagna, JA ;

Chung, RT ;

Schneyer, AL ;

Woolf, CJ ;

Andrews, NC ;

Lin, HY .

NATURE GENETICS, 2006, 38 (05) :531-539

[2] Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH [J].

Bekri, Soumeya ;

Gual, Philippe ;

Anty, Rodolphe ;

Luciani, Nathalie ;

Dahman, Monsef ;

Ramesh, Bala ;

Iannelli, Antonio ;

Staccini-Myx, Aline ;

Casanova, Dominique ;

Ben Amor, Imed ;

Saint-Paul, Marie-Christine ;

Huet, Pierre-Michel ;

Sadoul, Jean-Louis ;

Gugenheim, Jean ;

Srai, Surjit Kaila S. ;

Tran, Albert ;

Le Marchand-Brustel, Yannick .

GASTROENTEROLOGY, 2006, 131 (03) :788-796

[3] Evidence for differential effects of hepcidin in macrophages and intestinal epithelial cells [J].

Chaston, T. ;

Chung, B. ;

Mascarenhas, M. ;

Marks, J. ;

Patel, B. ;

Srai, S. K. ;

Sharp, P. .

GUT, 2008, 57 (03) :374-382

[4] The iron efflux protein ferroportin regulates the intracellular growth of Salmonella enterica [J].

Chlosta, S ;

Fishman, DS ;

Harrington, L ;

Johnson, EE ;

Knutson, MD ;

Wessling-Resnick, M ;

Cherayil, BJ .

INFECTION AND IMMUNITY, 2006, 74 (05) :3065-3067

[5] Hepcidin regulation: ironing out the details [J].

De Domenico, Ivana ;

Ward, Diane M. ;

Kaplan, Jerry .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (07) :1755-1758

[6] The molecular mechanism of hepcidin-mediated ferroportin down-regulation [J].

De Domenico, Ivana ;

Ward, Diane McVey ;

Langelier, Charles ;

Vaughn, Michael B. ;

Nemeth, Elizabeta ;

Sundquist, Wesley I. ;

Ganz, Tomas ;

Musci, Giovanni ;

Kaplan, Jerry .

MOLECULAR BIOLOGY OF THE CELL, 2007, 18 (07) :2569-2578

[7] STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation [J].

Falzacappa, Maria Vittoria Verga ;

Spasic, Maja Vujic ;

Kessler, Regina ;

Stolte, Jens ;

Hentze, Matthias W. ;

Muckenthaler, Martina U. .

BLOOD, 2007, 109 (01) :353-358

[8] Immunoassay for human serum hepcidin [J].

Ganz, Tomas ;

Olbina, Gordana ;

Girelli, Domenico ;

Nemeth, Elizabeta ;

Westerman, Mark .

BLOOD, 2008, 112 (10) :4292-4297

[9] Hepcidin expression in mouse retina and its regulation via lipopolysaccharide/Toll-like receptor-4 pathway independent of Hfe [J].

Gnana-Prakasam, Jaya P. ;

Martin, Pamela M. ;

Mysona, Barbara A. ;

Roon, Penny ;

Smith, Sylvia B. ;

Ganapathy, Vadivel .

BIOCHEMICAL JOURNAL, 2008, 411 (79-88) :79-88

[10] Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing [J].

Goswami, Tapasree ;

Andrews, Nancy C. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (39) :28494-28498

← 1 2 3 4 5 →