Theory and practice of nuclear spin relaxation in proteins

被引：135
|
作者：
Dayie, KT
Wagner, G
Lefevre, JF
机构：
[1] HARVARD UNIV, SCH MED, DEPT BIOL CHEM & MOL PHARMACOL, BOSTON, MA 02115 USA
[2] ESBS, GRP CANCEROGENESE & MUTAGENESE MOL & STRUCT, F-67400 STRASBOURG, FRANCE
来源：
ANNUAL REVIEW OF PHYSICAL CHEMISTRY | 1996年 / 47卷
关键词：
NMR of proteins; protein dynamics; model-free approach; molecular dynamics simulations; spectral density mapping;
D O I：
10.1146/annurev.physchem.47.1.243
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
NMR relaxation experiments can provide information on overall and internal motions in proteins. This review consists of a concise report on the evolution of the theories for nuclear relaxation followed by an overview of mathematical models for internal motions in proteins. Next, the method of spectral density mapping with recent developments is reviewed. This is followed by a discussion of pulse sequences for relaxation experiments. Finally, we review recent studies correlating relaxation parameters, in particular spectral density functions, with structural features of proteins and with results of molecular dynamics simulations.
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页码：243 / 282
页数：40
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