Reduced Interleukin-5 Production by Peripheral Cd4+T Cells in Common Variable Immunodeficiency Patients

被引：0

作者：

Del Vecchio, Giovanni Carlo ^{[1
]}

Martire, Baldassarre ^{[1
]}

Lassandro, Giuseppe ^{[1
]}

Cecinati, Valerio ^{[1
]}

De Mattia, Delia ^{[1
]}

Ciccarelli, Maria ^{[1
]}

Piacente, Laura ^{[1
]}

Giordano, Paola ^{[1
]}

机构：

[1] Univ Bari, Dept Biomed Dev Age, Policlin, I-70124 Bari, Italy

来源：

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | 2008年 / 30卷 / 04期

关键词：

Common Variable Immunodeficiency; Interleukin-5; Interleukin-4;

D O I：

10.1080/08923970802278102

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We evaluated the capacity of peripheral CD4+ T helper cells in four Common Variable Immunodeficiency (CVI) patients to secrete interleukin-4 (IL-4) and IL-5. While in control CD4+ T cells, stimulated via CD3 and cultured in presence of IL-2 or IL-15, a 10 fold increased production of IL-5 (146 +/- 30; 142 +/- 25 pg/ml) was found, a 4 fold increment of this cytokine was, instead, detected in 3 out of 4 CVI patients (34 +/- 13; 39 +/- 12 pg/ml) (p < 0.05). In conclusion, the reduction of IL-5, involved in the late regulation of B cell differentiation into Ig-secreting plasma cells, may contribute to the defective antibody production in CVI patients.

引用

页码：679 / 686

页数：8

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