Reduced Interleukin-5 Production by Peripheral Cd4+T Cells in Common Variable Immunodeficiency Patients

被引：0

作者：

Del Vecchio, Giovanni Carlo ^{[1
]}

Martire, Baldassarre ^{[1
]}

Lassandro, Giuseppe ^{[1
]}

Cecinati, Valerio ^{[1
]}

De Mattia, Delia ^{[1
]}

Ciccarelli, Maria ^{[1
]}

Piacente, Laura ^{[1
]}

Giordano, Paola ^{[1
]}

机构：

[1] Univ Bari, Dept Biomed Dev Age, Policlin, I-70124 Bari, Italy

来源：

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | 2008年 / 30卷 / 04期

关键词：

Common Variable Immunodeficiency; Interleukin-5; Interleukin-4;

D O I：

10.1080/08923970802278102

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We evaluated the capacity of peripheral CD4+ T helper cells in four Common Variable Immunodeficiency (CVI) patients to secrete interleukin-4 (IL-4) and IL-5. While in control CD4+ T cells, stimulated via CD3 and cultured in presence of IL-2 or IL-15, a 10 fold increased production of IL-5 (146 +/- 30; 142 +/- 25 pg/ml) was found, a 4 fold increment of this cytokine was, instead, detected in 3 out of 4 CVI patients (34 +/- 13; 39 +/- 12 pg/ml) (p < 0.05). In conclusion, the reduction of IL-5, involved in the late regulation of B cell differentiation into Ig-secreting plasma cells, may contribute to the defective antibody production in CVI patients.

引用

页码：679 / 686

页数：8

共 19 条

[1] ANTONACI S, 1992, Cytobios, V70, P77
[2] Cytokine and cytokine receptor expression as a biological indicator of immune activation: important considerations in the development of in vitro model systems
Collins, DP
[J]. JOURNAL OF IMMUNOLOGICAL METHODS, 2000, 243 (1-2) : 125 - 145
[3] Long-term low-dose IL-2 enhances immune function in common variable immunodeficiency
Cunningham-Rundles, C
Bodian, C
Ochs, HD
Martin, S
Reiter-Wong, M
Zhuo, Z
[J]. CLINICAL IMMUNOLOGY, 2001, 100 (02) : 181 - 190
[4] CLINICAL AND IMMUNOLOGICAL ANALYSES OF 103 PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY
CUNNINGHAMRUNDLES, C
[J]. JOURNAL OF CLINICAL IMMUNOLOGY, 1989, 9 (01) : 22 - 33
[5] FERRER JM, 1995, CLIN EXP IMMUNOL, V102, P286
[6] HERMASZEWSKI RA, 1993, Q J MED, V86, P31
[7] Abnormal interleukin-7 function in common variable immunodeficiency
Holm, AM
Aukrust, P
Damås, JK
Müller, F
Halvorsen, B
Froland, SS
[J]. BLOOD, 2005, 105 (07) : 2887 - 2890
[8] Impaired secretion of IL-10 by T cells from patients with common variable immunodeficiency-involvement of protein kinase A type I
Holm, AM
Aukrust, P
Aandahl, EM
Müller, F
Taskén, K
Froland, SS
[J]. JOURNAL OF IMMUNOLOGY, 2003, 170 (11) : 5772 - 5777
[9] HORIKAWA K, 1993, CELL IMMUNOL, V149, P390
[10] Interleukin-5 regulates genes involved in B-cell terminal maturation
Horikawa, Keisuke
Takatsu, Kiyoshi
[J]. IMMUNOLOGY, 2006, 118 (04) : 497 - 508

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