Modification of titanium surface with collagen and doxycycline as a new approach in dental implants

被引:35
|
作者
Corobea, Marijana Simina [1 ]
Albu, Madalina Georgiana [2 ]
Ion, Raluca [3 ]
Cimpean, Anisoara [3 ]
Miculescu, Florin [4 ]
Antoniac, Iulian Vasile [4 ]
Raditoiu, Valentin [5 ]
Sirbu, Ioan [1 ]
Stoenescu, Mihai [1 ]
Voicu, Stefan Ioan [6 ]
Ghica, Mihaela Violeta [7 ]
机构
[1] Carol Davila Univ Med & Pharm, Fac Med Dent, Bucharest 010209, Romania
[2] Leather & Footwear Res Inst, Collagen Dept, Bucharest 031215, Romania
[3] Univ Bucharest, Dept Biochem & Mol Biol, Bucharest 050095, Romania
[4] Univ Politehn Bucuresti, Fac Mat Sci & Engn, Bucharest 060042, Romania
[5] Natl Inst Res & Dev Chem & Petrochem, Bucharest 060021, Romania
[6] Univ Politehn Bucuresti, Fac Appl Chem & Mat Sci, Dept Analyt Chem & Environm Engn, Bucharest 011061, Romania
[7] Carol Davila Univ Med & Pharm, Dept Phys Chem, Fac Pharm, Bucharest 020956, Romania
关键词
titanium; collagen; doxycycline; drug delivery; osseointegration; IN-VITRO; DELIVERY-SYSTEMS; DRUG-DELIVERY; RELEASE; OSSEOINTEGRATION; ALLOY; VIVO;
D O I
10.1080/01694243.2015.1073661
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
In this work, we investigate for the first time several issues involved in bio-adhesion process for a new type of chemically modified titanium surfaces (in their initial form and after collagen deposition), in order to assess their potential in dental implant surface modification. For this purpose, we studied the following: collagen adhesion, cytotoxicity, osteoblast cytomorphology, cell adhesion and proliferation, doxycycline embedding and modifications in the collagen film deposed on the metal surfaces, drug release from the collagen films. The improvement of adhesion between collagen film and titanium substrate, when hydroxyl and amino functional groups are assisting the surfaces was presented, all materials showing no cytotoxic effects as revealed by lactate dehydrogenase-based assay. The drug release from titanium-coll-doxy systems offers a dual mechanism of the delivery profile (burst release followed by moderate discharge of the antibiotic), with perspectives in soft tissue recovery postoperative stage.
引用
收藏
页码:2537 / 2550
页数:14
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