Alkaloids from the seeds of Peganum harmala showing antiplasmodial and vasorelaxant activities

被引：103

作者：

Astulla, Adil ^{[1
]}

Zaima, Kazumasa ^{[1
]}

Matsuno, Yosuke ^{[1
]}

Hirasawa, Yusuke ^{[1
]}

Ekasari, Wiwied ^{[2
]}

Widyawaruyanti, Aty ^{[2
]}

Zaini, Noor Cholies ^{[2
]}

Morita, Hiroshi ^{[1
]}

机构：

[1] Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, Japan

[2] Airlangga Univ, Fac Pharm, Jalan Dharmawangsa Dalam 60286, Surabaya, Indonesia

来源：

JOURNAL OF NATURAL MEDICINES | 2008年 / 62卷 / 04期

关键词：

Peganum harmala; antiplasmodial activity; vasorelaxant activity; harmine; harmaline; vasicinone; deoxyvasicinone;

D O I：

10.1007/s11418-008-0259-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Bioassay-guided purification from the seeds of Peganum harmala led to the isolation of harmine (1), harmaline (2), vasicinone (3), and deoxyvasicinone (4). Harmine (1) and harmaline (2) showed a moderate in vitro antiplasmodial activity against Plasmodium falciparum. Quinazoline alkaloid, vasicinone (3), showed a vasorelaxant activity against phenylephrine-induced contraction of isolated rat aorta.

引用

页码：470 / 472

页数：3

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