Alkaloids from the seeds of Peganum harmala showing antiplasmodial and vasorelaxant activities

被引：103
作者：
Astulla, Adil [1 ]
Zaima, Kazumasa [1 ]
Matsuno, Yosuke [1 ]
Hirasawa, Yusuke [1 ]
Ekasari, Wiwied [2 ]
Widyawaruyanti, Aty [2 ]
Zaini, Noor Cholies [2 ]
Morita, Hiroshi [1 ]
机构：
[1] Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, Japan
[2] Airlangga Univ, Fac Pharm, Jalan Dharmawangsa Dalam 60286, Surabaya, Indonesia
来源：
JOURNAL OF NATURAL MEDICINES | 2008年 / 62卷 / 04期
关键词：
Peganum harmala; antiplasmodial activity; vasorelaxant activity; harmine; harmaline; vasicinone; deoxyvasicinone;
D O I：
10.1007/s11418-008-0259-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Bioassay-guided purification from the seeds of Peganum harmala led to the isolation of harmine (1), harmaline (2), vasicinone (3), and deoxyvasicinone (4). Harmine (1) and harmaline (2) showed a moderate in vitro antiplasmodial activity against Plasmodium falciparum. Quinazoline alkaloid, vasicinone (3), showed a vasorelaxant activity against phenylephrine-induced contraction of isolated rat aorta.
引用
收藏
页码：470 / 472
页数：3
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