p16 expression is not associated with human papillomavirus in urinary bladder squamous cell carcinoma

被引：57

作者：

Alexander, Riley E. ^{[1
]}

Hu, Yingchuan ^{[1
]}

Kum, Jennifer B. ^{[1
]}

Montironi, Rodolfo ^{[2
]}

Lopez-Beltran, Antonio ^{[3
]}

MacLennan, Gregory T. ^{[4
]}

Idrees, Muhammad T. ^{[1
]}

Emerson, Robert E. ^{[1
]}

Ulbright, Thomas M. ^{[1
]}

Grignon, David G. ^{[1
]}

Eble, John N. ^{[1
]}

Cheng, Liang ^{[1
]}

机构：

[1] Indiana Univ Sch Med, Dept Pathol & Lab Med, Indianapolis, IN 46202 USA

[2] United Hosp, Polytech Univ Marche Reg Ancona, Sch Med, Inst Pathol Anat & Histopathol, Ancona, Italy

[3] Univ Cordoba, Dept Pathol, Cordoba, Spain

[4] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA

来源：

MODERN PATHOLOGY | 2012年 / 25卷 / 11期

关键词：

human papillomavirus; in situ hybridization; immunohistochemistry; p16; squamous cell carcinoma; urinary bladder; HIGH-RISK; CERVICAL NEOPLASIA; P16(INK4A) IMMUNOHISTOCHEMISTRY; INTRAEPITHELIAL NEOPLASIA; UTERINE CERVIX; CANCER; INFECTION; HPV; DIAGNOSIS; OVEREXPRESSION;

D O I：

10.1038/modpathol.2012.103

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Squamous cell carcinoma of the urinary bladder is unusual and of unknown etiology. There is a well-established association between human papillomavirus (HPV) infection and the development of cervical and head/neck squamous cell carcinomas. However, the role of HPV in the pathogenesis of squamous cell carcinoma of the urinary bladder is uncertain. The purposes of this study were to investigate the possible role of HPV in the development of squamous cell carcinoma of the urinary bladder and to determine if p16 expression could serve as a surrogate marker for HPV in this malignancy. In all, 42 cases of squamous cell carcinoma of the urinary bladder and 27 cases of urothelial carcinoma with squamous differentiation were investigated. HPV infection was analyzed by both in situ hybridization at the DNA level and immunohistochemistry at the protein level. p16 protein expression was analyzed by immunohistochemistry. HPV DNA and protein were not detected in 42 cases of squamous cell carcinoma (0%, 0/42) or 27 cases of urothelial carcinoma with squamous differentiation (0%, 0/15). p16 expression was detected in 13 cases (31%, 13/42) of squamous cell carcinoma and 9 cases (33%, 9/27) of urothelial carcinoma with squamous differentiation. There was no correlation between p16 expression and the presence of HPV infection in squamous cell carcinoma of the bladder or urothelial carcinoma with squamous differentiation. Our data suggest that HPV does not play a role in the development of squamous cell carcinoma of the urinary bladder or urothelial carcinoma with squamous differentiation. p16 expression should not be used as a surrogate marker for evidence of HVP infection in either squamous cell carcinoma of the urinary bladder or urothelial carcinoma with squamous differentiation as neither HVP DNA nor protein is detectable in these neoplasms. Modern Pathology (2012) 25, 1526-1533; doi: 10.1038/modpathol.2012.103; published online 8 June 2012

引用

页码：1526 / 1533

页数：8

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