Potent inhibitory effect of the cyclolignan picropodophyllin (PPP) on human adrenocortical carcinoma cells proliferation

被引：0

作者：

Doghman, Mabrouka ^{[1
,2
]}

Axelson, Magnus ^{[3
]}

Lalli, Enzo ^{[1
,2
]}

机构：

[1] CNRS, Inst Pharmacol Mol & Cellulaire, UMR 6097, F-06560 Valbonne, France

[2] Univ Nice Sophia Antipolis, Valbonne, France

[3] Karolinska Univ Hosp, Dept Clin Chem, Stockholm, Sweden

来源：

AMERICAN JOURNAL OF CANCER RESEARCH | 2011年 / 1卷 / 03期

关键词：

Adrenal cortex; cancer; IGF receptor; cell lines;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Adrenocortical carcinoma (ACC) is a very aggressive tumor with a poor prognosis. Available treatments for this type of cancer are far from being satisfactory. The IGF signalling pathway represents an important mechanism for ACT growth and constitutes a relevant therapeutic target. We investigated the effect of picropodophyllin (PPP), a member of the cyclolignan family and a new inhibitor of IGF-1R, on proliferation of human adrenocortical cell lines H295R and SW-13. PPP inhibits proliferation and induces an important accumulation in G2/ M phase and apoptosis of H295R and SW-13 cells. Our data suggest that PPP may be a promising candidate for drug development for adrenocortical carcinoma.

引用

页码：356 / 361

页数：6

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