Potent inhibitory effect of the cyclolignan picropodophyllin (PPP) on human adrenocortical carcinoma cells proliferation

被引：0
作者：
Doghman, Mabrouka [1 ,2 ]
Axelson, Magnus [3 ]
Lalli, Enzo [1 ,2 ]
机构：
[1] CNRS, Inst Pharmacol Mol & Cellulaire, UMR 6097, F-06560 Valbonne, France
[2] Univ Nice Sophia Antipolis, Valbonne, France
[3] Karolinska Univ Hosp, Dept Clin Chem, Stockholm, Sweden
来源：
AMERICAN JOURNAL OF CANCER RESEARCH | 2011年 / 1卷 / 03期
关键词：
Adrenal cortex; cancer; IGF receptor; cell lines;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Adrenocortical carcinoma (ACC) is a very aggressive tumor with a poor prognosis. Available treatments for this type of cancer are far from being satisfactory. The IGF signalling pathway represents an important mechanism for ACT growth and constitutes a relevant therapeutic target. We investigated the effect of picropodophyllin (PPP), a member of the cyclolignan family and a new inhibitor of IGF-1R, on proliferation of human adrenocortical cell lines H295R and SW-13. PPP inhibits proliferation and induces an important accumulation in G2/ M phase and apoptosis of H295R and SW-13 cells. Our data suggest that PPP may be a promising candidate for drug development for adrenocortical carcinoma.
引用
收藏
页码：356 / 361
页数：6
相关论文
共 50 条
  • [31] Nudix-type motif 2 in human breast carcinoma: a potent prognostic factor associated with cell proliferation
    Oka, Kimako
    Suzuki, Takashi
    Onodera, Yoshiaki
    Miki, Yasuhiro
    Takagi, Kiyoshi
    Nagasaki, Shuji
    Akahira, Jun-Ichi
    Ishida, Takanori
    Watanabe, Mika
    Hirakawa, Hisashi
    Ohuchi, Noriaki
    Sasano, Hironobu
    INTERNATIONAL JOURNAL OF CANCER, 2011, 128 (08) : 1770 - 1782
  • [32] The Potent Inhibitory Effect of a Naproxen-Appended Cobalt(III)-Cyclam Complex on Cancer Stem Cells
    Cressey, Paul B.
    Eskandari, Arvin
    Bruno, Peter M.
    Lu, Chunxin
    Hemann, Michael T.
    Suntharalingam, Kogularamanan
    CHEMBIOCHEM, 2016, 17 (18) : 1713 - 1718
  • [33] Gemcitabine-releasing mesenchymal stromal cells inhibit in vitro proliferation of human pancreatic carcinoma cells
    Bonomi, Arianna
    Sordi, Valeria
    Dugnani, Erica
    Ceserani, Valentina
    Dossena, Marta
    Cocce, Valentina
    Cavicchini, Loredana
    Ciusanj, Emilto
    Bondiolotti, Gianpietro
    Piovani, Giovanna
    Pascucci, Luisa
    Sisto, Francesca
    Alessandri, Giulio
    Piemonti, Lorenzo
    Parati, Eugenjo
    Pessina, Augusto
    CYTOTHERAPY, 2015, 17 (12) : 1687 - 1695
  • [34] Inhibitory Effect of Semen Litchi Drug Serum on the Proliferation of Human Hepatoma HepG2 Cells and Expression of VEGF and MMP-9
    Zhao, Lichun
    Yu, Peiliang
    Yang, Tao
    Zhou, Gailian
    Tang, Nong
    JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN, 2019, 29 (06): : 532 - 536
  • [35] Preliminary study on the inhibitory effect of tumor suppressor gene KPC1 on the proliferation in gastric carcinoma cell
    Zhou, Min
    Qu, Chun-Ying
    Ding, Wen-Jin
    Cai, Xiao-Lei
    Shen, Yu-Jie
    Chen, Ying-Wei
    Xu, Lei-Ming
    ANNALS OF TRANSLATIONAL MEDICINE, 2020, 8 (06)
  • [36] Modulation of cell proliferation and differentiation of human lung carcinoma cells by the interferon-alpha
    Krejcova, Daniela
    Prochazkova, Jirina
    Kubala, Lukas
    Pachernik, Jiri
    GENERAL PHYSIOLOGY AND BIOPHYSICS, 2009, 28 (03) : 294 - 301
  • [37] Hiwi downregulation, mediated by shRNA, reduces the proliferation and migration of human hepatocellular carcinoma cells
    Xie, Yingjun
    Yang, Yongsheng
    Ji, Degang
    Zhang, Dan
    Yao, Xiaoxiao
    Zhang, Xuewen
    MOLECULAR MEDICINE REPORTS, 2015, 11 (02) : 1455 - 1461
  • [38] Inhibitory effects of petasin on human colon carcinoma cells mediated by inactivation of Akt/mTOR pathway
    Lyu, Xi
    Song, Ai-Lin
    Bai, Yin-Liang
    Xu, Xiao-Dong
    He, Dong-Qiang
    Zhang, You-Cheng
    CHINESE MEDICAL JOURNAL, 2019, 132 (09) : 1071 - 1078
  • [39] Knockdown of TACC3 Inhibits the Proliferation and Invasion of Human Renal Cell Carcinoma Cells
    Guo, Feng
    Liu, Yaquan
    ONCOLOGY RESEARCH, 2018, 26 (02) : 183 - 189
  • [40] Effects of HSP70 Antisense Oligonucleotide on the Proliferation and Apoptosis of Human Hepatocellular Carcinoma Cells
    Yang, Xue
    He, Haibin
    Yang, Wei
    Song, Tao
    Guo, Cheng
    Zheng, Xin
    Liu, Qingguang
    JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES, 2010, 30 (03) : 337 - 343
12345