Potent inhibitory effect of the cyclolignan picropodophyllin (PPP) on human adrenocortical carcinoma cells proliferation

被引：0
|
作者：
Doghman, Mabrouka [1 ,2 ]
Axelson, Magnus [3 ]
Lalli, Enzo [1 ,2 ]
机构：
[1] CNRS, Inst Pharmacol Mol & Cellulaire, UMR 6097, F-06560 Valbonne, France
[2] Univ Nice Sophia Antipolis, Valbonne, France
[3] Karolinska Univ Hosp, Dept Clin Chem, Stockholm, Sweden
来源：
AMERICAN JOURNAL OF CANCER RESEARCH | 2011年 / 1卷 / 03期
关键词：
Adrenal cortex; cancer; IGF receptor; cell lines;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Adrenocortical carcinoma (ACC) is a very aggressive tumor with a poor prognosis. Available treatments for this type of cancer are far from being satisfactory. The IGF signalling pathway represents an important mechanism for ACT growth and constitutes a relevant therapeutic target. We investigated the effect of picropodophyllin (PPP), a member of the cyclolignan family and a new inhibitor of IGF-1R, on proliferation of human adrenocortical cell lines H295R and SW-13. PPP inhibits proliferation and induces an important accumulation in G2/ M phase and apoptosis of H295R and SW-13 cells. Our data suggest that PPP may be a promising candidate for drug development for adrenocortical carcinoma.
引用
收藏
页码：356 / 361
页数：6
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