U-shaped dose response in behavioral pharmacology: Historical foundations

被引：49

作者：

Calabrese, Edward J. ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Publ Hlth & Hlth Sci, Environm Hlth Sci Div, Dept Publ Hlth, Amherst, MA 01003 USA

来源：

CRITICAL REVIEWS IN TOXICOLOGY | 2008年 / 38卷 / 07期

关键词：

acetone; biphasic; CS2; dose-response; fixed interval; fixed ratio; hormesis; hormetic; TCE; toluene; triadimefon; U-shaped;

D O I：

10.1080/10408440802026307

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

This article assesses the historical foundations of U-shaped dose-responses in behavioral pharmacology and toxicology with particular emphasis on schedules of reinforcement. Quantitative features of the drug dose response, which are consistent with the hormetic dose response model, are detailed along with possible mechanistic foundations to account for low-dose stimulation and high-dose inhibition responses. The article provides a reinterpretation of the biphasic dose response in the fixed interval (FI) schedule of reinforcement.

引用

页码：591 / 598

页数：8

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