Beta-Adrenergic Receptors, from Their Discovery and Characterization through Their Manipulation to Beneficial Clinical Application

被引：96
作者：
Wachter, S. Blake [1 ]
Gilbert, Edward M. [1 ]
机构：
[1] Univ Utah, Div Cardiol, Salt Lake City, UT 84112 USA
来源：
CARDIOLOGY | 2012年 / 122卷 / 02期
关键词：
beta-Adrenergic receptors; G protein; beta-Blockers; CHRONIC HEART-FAILURE; IDIOPATHIC DILATED CARDIOMYOPATHY; HUMAN VENTRICULAR MYOCARDIUM; RANDOMIZED INTERVENTION TRIAL; FAILING HUMAN-HEART; TRANSGENIC MICE; DOWN-REGULATION; BETA-1-ADRENERGIC RECEPTORS; BETA(2)-ADRENERGIC RECEPTOR; BETA(1)-ADRENERGIC RECEPTOR;
D O I：
10.1159/000339271
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
beta-Adrenergic receptors (beta-AR) are central to the overall regulation of cardiac function. From the first proposed receptor/transmitter concept to the latest clinical beta-blocker trials beta-AR have been shown to play an important role in cardiac disease and heart failure in particular. This study provides a historical perspective, reviews the latest discoveries and beliefs, and discusses the current clinical practices of beta-AR and their modulation with their associated guanine-nucleotide regulatory protein/adenylylcyclasesignal transduction pathways. Copyright (c) 2012 S. Karger AG, Basel
引用
收藏
页码：104 / 112
页数：9
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