Patterns of long acting injectable antipsychotic use and associated clinical factors in schizophrenia among 15 Asian countries and region

被引:29
作者
Tang, Chao Tian [1 ]
Chua, Ee Cheong [1 ]
Chew, Qian Hui [1 ]
He, Yan-Ling [2 ]
Si, Tian-Mei [3 ]
Chiu, Helen F-K [4 ]
Xiang, Yu-Tao [5 ]
Kato, Takahiro A. [6 ]
Kanba, Shigenobu [6 ]
Shinfuku, Naotaka [7 ]
Lee, Min-Soo [8 ]
Park, Seon-Cheol [9 ]
Park, Yong-Chon [10 ]
Chong, Mian-Yoon [11 ,12 ]
Lin, Shih-Ku [13 ,14 ]
Yang, Shu-Yu [13 ,14 ]
Tripathi, Adarsh [15 ]
Avasthi, Ajit [16 ]
Grover, Sandeep [16 ]
Kallivayalil, Roy A. [17 ]
Udomratn, Pichet [18 ]
Chee, Kok Yoon [19 ]
Tanra, Andi J. [20 ]
Rabbani, Md Golam [21 ]
Javed, Afzal [22 ]
Kathiarachchi, Samudra [23 ]
Waas, Dulshika [23 ]
Myint, Wing Aung [24 ]
Sartorius, Norman [25 ]
Van Cuong Tran [26 ]
Kim Viet Nguyen [26 ]
Tan, Chay-Hoon [27 ]
Baldessarini, Ross J. [28 ]
Sim, Kang [1 ]
机构
[1] Buangkok Green Med Pk, Inst Mental Hlth, Singapore, Singapore
[2] Shanghai Mental Hlth Ctr, Dept Psychiat Epidemiol, Shanghai, Peoples R China
[3] Peking Univ, Inst Mental Hlth, Beijing, Peoples R China
[4] Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Peoples R China
[5] Univ Macau, Ctr Cognit & Brain Sci, Macau, Peoples R China
[6] Kyushu Univ, Grad Sch Med, Dept Neuropsychiat, Fukuoka, Japan
[7] Kobe Univ, Dept Psychiat, Kobe, Hyogo, Japan
[8] Korea Univ, Coll Med, Dept Psychiat, Seoul, South Korea
[9] Inje Univ, Dept Psychiat, Haeundae Paik Hosp, Busan, South Korea
[10] Hanyang Univ, Dept Neuropsychiat, Guri Hosp, Guri, South Korea
[11] Kaoshiung Chang Gung Mem Hosp, Dept Psychiat, Kaohsiung, Taiwan
[12] Chang Gung Univ, Sch Med, Kaohsiung, Taiwan
[13] Taipei City Hosp, Dept Pharm, Taipei, Taiwan
[14] Fu Jen Catholic Univ, Taipei, Taiwan
[15] King Georges Med Univ, Dept Psychiat, Lucknow, Uttar Pradesh, India
[16] Post Grad Inst Med Educ & Res PGIMER, Dept Psychiat, Chandigarh, India
[17] Pushpagiri Inst Med Sci, Dept Psychiat, Tiruvalla, India
[18] Prince Songkla Univ, Fac Med, Dept Psychiat, Hat Yai, Thailand
[19] Tunku Abdul Rahman Inst Neurosci, Dept Psychiat & Mental Hlth, Kuala Lumpur, Malaysia
[20] Hasanuddin Univ, Dept Psychiat, Fac Med, Makassar, Indonesia
[21] Bangladesh Assoc Psychiatrists, Dhaka, Bangladesh
[22] Pakistan Psychiat Res Ctr, Fountain House, Lahore, Pakistan
[23] Univ Sri Jayewardenepura, Dept Psychiat, Nugegoda, Sri Lanka
[24] Myanmar Med Assoc, Mental Hlth Soc, Yangon, Myanmar
[25] Assoc Improvement Mental Hlth Programmes, Geneva, Switzerland
[26] Vietnam Psychiat Assoc VPA, Hanoi, Vietnam
[27] Natl Univ Singapore Hosp, Dept Pharmacol, Singapore, Singapore
[28] McLean Hosp, Int Consortium Mood & Psychot Disorder Res, 115 Mill St, Belmont, MA 02178 USA
关键词
antipsychotic drugs; long-acting injectable; schizophrenia; FACTORS INFLUENCING ADHERENCE; MEDICATION ADHERENCE; DEPOT; NONADHERENCE; FORMULATIONS; RISPERIDONE; PREVENTION; INJECTIONS; NATIONWIDE; RELAPSE;
D O I
10.1111/appy.12393
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Introduction Patterns of clinical use of long-acting injectable (LAI) antipsychotic drugs in many countries, especially in Asia, for treatment of patients diagnosed with chronic psychotic disorders including schizophrenia are not well established. Methods Within an extensive research consortium, we evaluated prescription rates for first- (FGA) and second-generation antipsychotic (SGA) LAI drugs and their clinical correlates among 3557 subjects diagnosed with schizophrenia across 15 Asian countries and region. Results Overall, an average of 17.9% (638/3557; range: 0.0%-44.9%) of treated subjects were prescribed LAI antipsychotics. Those given LAI vs orally administered agents were significantly older, had multiple hospitalizations, received multiple antipsychotics more often, at 32.4% higher doses, were more likely to manifest disorganized behavior or aggression, had somewhat superior psychosocial functioning and less negative symptoms, but were more likely to be hospitalized, with higher BMI, and more tremor. Being prescribed an FGA vs SGA LAI agent was associated with male sex, aggression, disorganization, hospitalization, multiple antipsychotics, higher doses, with similar risks of adverse neurological or metabolic effects. Rates of use of LAI antipsychotic drugs to treat patients diagnosed with schizophrenia varied by more than 40-fold among Asian countries and given to an average of 17.9% of treated schizophrenia patients. We identified the differences in the clinical profiles and treatment characteristics of patients who were receiving FGA-LAI and SGA-LAI medications. Discussion These findings behoove clinicians to be mindful when evaluating patients' need to be on LAI antipsychotics amidst multifaceted considerations, especially downstream adverse events such as metabolic and extrapyramidal side effects.
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