One-Pot, Two-Step Synthesis of Imidazo[1,2-a]benzimidazoles via A Multicomponent [4+1] Cycloaddition Reaction

被引：23
|
作者：
Hsiao, Ya-Shan [1 ]
Narhe, Bharat D. [1 ]
Chang, Ying-Sheng [1 ]
Sun, Chung-Ming [1 ]
机构：
[1] Natl Chiao Tung Univ, Dept Appl Chem, Hsinchu 30010, Taiwan
来源：
ACS COMBINATORIAL SCIENCE | 2013年 / 15卷 / 10期
关键词：
microwave irradiation; 4+1] cycloaddition; imidazo[1,2-a]benzimidazoles; three-component reaction; DESIGN;
D O I：
10.1021/co400075z
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A one-pot, two-step synthesis of imidazo[1,2-a]benzimidazoles has been achieved by a three-component reaction of 2-aminobenzimidazoles with an aromatic aldehyde and an isocyanide. The reaction involving condensation of 2-aminobenzimidazole with an aldehyde is run under microwave activation to generate an imine intermediate under basic conditions which then undergoes [4 + 1] cycloaddition with an isocyanide.
引用
收藏
页码：551 / 555
页数：5
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