Editorial: The role of omics characteristics in the diagnosis, treatment, and prognosis of autoimmune diseases

被引：0

作者：

Wu, Qinglong ^{[1
]}

Ning, Kang ^{[2
]}

Zhao, Xiaoxiao ^{[3
]}

Liao, Feng ^{[3
]}

Wang, Min ^{[3
,4
]}

Chang, Longgang ^{[3
]}

Liu, Yanmin ^{[4
]}

Chen, Jinmiao ^{[5
,6
]}

Zhao, Ming ^{[7
]}

Chen, Zhangran ^{[3
,4
,8
]}

机构：

[1] Baylor Coll Med, Texas Childrens Microbiome Ctr, Houston, TX USA

[2] Huazhong Univ Sci & Technol, Sch Life Sci & Technol, Wuhan, Peoples R China

[3] Shenzhen Wedge Microbiol Res Co Ltd, Shenzhen, Peoples R China

[4] Inner Mongolia Shuangqi Pharmaceut Co Ltd, Hohhot, Peoples R China

[5] ASTAR, Singapore Immunol Network SIgN, Singapore, Singapore

[6] Natl Univ Singapore NUS, Yong Loo Lin Sch Med, Dept Microbiol & Immunol, Immunol Translat Res Program, Singapore, Singapore

[7] Cent South Univ, Xiangya Hosp 2, Changsha, Peoples R China

[8] Xiamen Univ, Zhongshan Hosp, Dept Gastroenterol, Xiamen, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

基金：

中国国家自然科学基金;

关键词：

autoimmune diseases; biomarker; microRNAs; fecal microbiota; rheumatoid arthritis; omics technology;

D O I：

10.3389/fimmu.2022.1069918

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoimmune diseases (ADs) represent a type of disease that causes damage to the body due to the disorder of autoantigen immune tolerance and host immune responses to autoantigens. Such defects could affect any part of the body, i.e. weakening bodily function and even turning life-threatening consequences. The incidence of ADs has increased over the past decade, affecting 5% to 8% of the world population and posing great challenge to the healthcare system. Up to now, more than eighty types of autoimmune diseases have been clinically identified. In addition to protect the host against infections, cancers and other diseases, the immune system also produces elevated levels of inflammatory cytokines and auto-antibodies that could induce complex autoimmune disorders (AIDs), such as Type I diabetes ( T1D), primary biliary cirrhosis (PBC), rheumatoid arthritis (RA), multiple sclerosis (MS), autoimmune liver disease (ALD), systemic lupus erythematosus (SLE), ankylosing spondylitis (AS), Sjogren syndrome (SS), and polymyositis/dermatomyositis, etc. However, the pathogenesis of ADs and many other diseases, especially certain types of cancers, still remains elusive and needs to be illuminated systematically.

引用

页数：3