Reversible Posterior Leuko-Encephalopathy in Children With Sickle Cell Disease

被引：25

作者：

Khademian, Zarir ^{[2
]}

Speller-Brown, Barbara ^{[3
]}

Nouraie, Seyed-Medhi ^{[4
]}

Minniti, Caterina P. ^{[1
]}

机构：

[1] NHLBI, NIH, Pulm & Vasc Med Branch, Bethesda, MD 20892 USA

[2] George Washington Univ, Childrens Natl Med Ctr, Dept Radiol, Washington, DC USA

[3] Ctr Canc & Blood Disorders, Childrens Natl Med Ctr, Washington, DC USA

[4] Howard Univ, Ctr Sickle Cell Dis, Washington, DC 20059 USA

来源：

PEDIATRIC BLOOD & CANCER | 2009年 / 52卷 / 03期

关键词：

hemoglobinopathies; neurology and sickle cell; sickle cell disease; LEUKOENCEPHALOPATHY SYNDROME; RELATIVE HYPERTENSION; RISK FACTOR; STROKE; ANEMIA;

D O I：

10.1002/pbc.21812

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Children with sickle cell disease (SCD) have high risk of neurologic morbidity and mortality, such as strokes, silent infarcts, and IIA's. A retrospective review of magnetic resonance imaging and magnetic resonance angiography identified eight children with radiological and clinical characteristics of reversible posterior em ephalopathy (RPLS). These patients had no evidence of previous cerebral infarcts or vasculopathy. Three have died during the 5-year follow up; one developed a stroke and one a conditional TCD. RPLS needs to be considered in the differential diagnosis of children with SCD that present with acute neurological changes, especially if they are already been hospitalized. Pediatr Blood Cancer 2009;52:373-375. (C) 2008 Wiley-Liss, Inc.

引用

页码：373 / 375

页数：3

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